Cell Senescence Entries for RPTOR
- Cell Types
- Nucleus pulposus
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Ito et al. (2018) Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction. Osteoarthritis Cartilage 25(12)2134-2146 (PubMed)
RPTOR Gene Information
- HGNC symbol
- RPTOR
- Aliases
- KIAA1303; KOG1; Mip1; raptor
- Common name
- regulatory associated protein of MTOR complex 1
- Entrez Id
- 57521
- Description
- This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
RPTOR Ontologies
- Gene Ontology
-
Process: GO:31929; TOR signaling
GO:43086; negative regulation of catalytic activity
GO:9410; response to xenobiotic stimulus
GO:32147; activation of protein kinase activity
GO:71230; cellular response to amino acid stimulus
GO:71902; positive regulation of protein serine/threonine kinase activity
GO:1558; regulation of cell growth
GO:8361; regulation of cell size
GO:32008; positive regulation of TOR signaling
GO:35176; social behavior
GO:31669; cellular response to nutrient levels
And 20 more GO terms Cellular component: GO:31931; TORC1 complex
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5765; lysosomal membrane
GO:5764; lysosome
GO:10494; cytoplasmic stress granule
GO:30425; dendrite
GO:43025; neuronal cell body
Function: GO:5515; protein binding
GO:19901; protein kinase binding
GO:44877; protein-containing complex binding
GO:71889; 14-3-3 protein binding
GO:30674; protein-macromolecule adaptor activity
GO:1002; RNA polymerase III type 1 promoter sequence-specific DNA binding
GO:1003; RNA polymerase III type 2 promoter sequence-specific DNA binding
GO:1006; RNA polymerase III type 3 promoter sequence-specific DNA binding
GO:1156; TFIIIC-class transcription factor complex binding
GO:30291; protein serine/threonine kinase inhibitor activity
GO:30295; protein kinase activator activity
And 1 more GO terms
Homologs of RPTOR in Model Organisms
- Caenorhabditis elegans
- daf-15
- Danio rerio
- rptor
- Drosophila melanogaster
- raptor
- Mus musculus
- Rptor
- Rattus norvegicus
- Rptor
- Saccharomyces cerevisiae
- KOG1
- Schizosaccharomyces pombe
- mip1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as daf-15
- LongevityMap
- This gene is present as RPTOR
External links
- OMIM
- 607130
- Ensembl
- ENSG00000141564
- Entrez Gene
- 57521
- UniGene
- 133044
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- RPTOR
- GeneCards
- RPTOR