LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Turkish
- Study Design
- 354 individuals (18 - 95 years, mean age 55.35 ± 19.16 y; 175 females (20–95 years, mean age 55.44 ± 19.15 years) and 179 males (18–92 years, mean age 55.27 ± 19.22 years) were classified into four age groups as 20–40, 41–60, 61–80, >80. Then, IL-6 and MT2A polymorphisms were genotyped for longevity association study.
- Conclusions
- A highly statistically significant association was detected for IL-6 genotype and allele frequencies in aging (p < 0.001). No significant difference was found between the two genders (p > 0.05). IL-6 −174 C+ carriers are more advantageous for longevity.
- Identifier
- rs1800795
- In Other Studies (IDs)
- 327 2108 2623
- Cytogenetic Location
- 7p15.3
- UCSC Genome Browser
- View 7p15.3 on the UCSC genome browser
Gene details
- HGNC symbol
- IL6
- Aliases
- CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2
- Common name
- interleukin 6
- Description
- This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
- Other longevity studies of this gene
- 19
- OMIM
- 147620
- Ensembl
- ENSG00000136244
- UniProt/Swiss-Prot
- B4DNQ5_HUMAN
- Entrez Gene
- 3569
- UniGene
- 654458
- HapMap
- View on HapMap