Cell Senescence Entries for IL6

Cell Types
Fibroblast
Cell Lines
TIG-3
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced, Stress-induced
Senescence Effect
Induces
Primary Reference
Kuilman et al. (2008) Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 133(6)1019-31 (PubMed)

IL6 Gene Information

HGNC symbol
IL6 
Aliases
BSF2; HGF; HSF; IFNB2; IL-6 
Common name
interleukin 6 
Entrez Id
3569
Description
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Aug 2020].

IL6 Ontologies

Gene Ontology
Process: GO:10628; positive regulation of gene expression
GO:43066; negative regulation of apoptotic process
GO:7165; signal transduction
GO:45893; positive regulation of transcription, DNA-templated
GO:6955; immune response
GO:43065; positive regulation of apoptotic process
GO:6953; acute-phase response
GO:46427; positive regulation of receptor signaling pathway via JAK-STAT
GO:98586; cellular response to virus
GO:8284; positive regulation of cell population proliferation
GO:72540; T-helper 17 cell lineage commitment
And 80 more GO terms
Cellular component: GO:5615; extracellular space
GO:5576; extracellular region
GO:5788; endoplasmic reticulum lumen
GO:5896; interleukin-6 receptor complex
Function: GO:5515; protein binding
GO:5125; cytokine activity
GO:8083; growth factor activity
GO:5102; signaling receptor binding
GO:5138; interleukin-6 receptor binding
Show all GO terms

Homologs of IL6 in Model Organisms

Mus musculus
Il6
Rattus norvegicus
Il6

In other databases

GenAge human genes
  • This gene is present as IL6
LongevityMap
  • This gene is present as IL6

External links

OMIM
147620
Ensembl
ENSG00000136244
Entrez Gene
3569
UniGene
654458
1000 Genomes
1000 Genomes
HPRD
GenAtlas
IL6
GeneCards
IL6