LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Danish
- Study Design
- SNPs rs4880 in MnSOD and rs1050450 in GPX1 were genotyped in 1650 individuals from the Danish 1905 cohort (follow-up time: 1998–2008, age at intake: 92–93 years, number of deaths: 1589 (96.3%)) and investigated for the association with aging and longevity
- Conclusions
- Decreased mortality of individuals holding either the MnSOD rs4880 C or the GPX1 rs1050450 T alleles (HR (MnSOD(CC/CT)) = 0.91, p = 0.002), HR (GPX1(TT/TC)) = 0.93, p = 0.008)) was observed, as well as a synergetic effect (HR = 0.76, p = 0.001). Genetic variation in MnSOD and GPX1 may be associated with aging and longevity.
- Identifier
- rs4880
- In Other Studies (IDs)
- 2285 2655
- Cytogenetic Location
- 6q25.3
- UCSC Genome Browser
- View 6q25.3 on the UCSC genome browser
Gene details
- HGNC symbol
- SOD2
- Aliases
- IPOB; IPO-B; MNSOD; MVCD6; Mn-SOD
- Common name
- superoxide dismutase 2
- Description
- This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]
- Other longevity studies of this gene
- 21
- OMIM
- 147460
- Ensembl
- ENSG00000112096
- UniProt/Swiss-Prot
- A0A0C4DFU1_HUMAN
- Entrez Gene
- 6648
- UniGene
- 487046
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- sod-3
- Danio rerio
- sod2
- Drosophila melanogaster
- Sod2
- Mus musculus
- Sod2
- Rattus norvegicus
- Sod2
- Saccharomyces cerevisiae
- SOD2
- Schizosaccharomyces pombe
- SPBC16A3.14