Cell Senescence Entries for SOD2
- Cell Types
- Prostate epithelial
- Cell Lines
- M12
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Plymate et al. (2003) Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1. Oncogene 22(7)1024-34 (PubMed)
SOD2 Gene Information
- HGNC symbol
- SOD2
- Aliases
- GClnc1
- Common name
- superoxide dismutase 2
- Entrez Id
- 6648
- Description
- This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016].
SOD2 Ontologies
- Gene Ontology
-
Process: GO:6357; regulation of transcription by RNA polymerase II
GO:72593; reactive oxygen species metabolic process
GO:6801; superoxide metabolic process
GO:302; response to reactive oxygen species
GO:303; response to superoxide
GO:1306; age-dependent response to oxidative stress
GO:1666; response to hypoxia
GO:1836; release of cytochrome c from mitochondria
GO:1889; liver development
GO:3032; detection of oxygen
GO:3069; acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure
And 61 more GO terms Cellular component: GO:5739; mitochondrion
GO:5759; mitochondrial matrix
GO:5737; cytoplasm
GO:42645; mitochondrial nucleoid
GO:70062; extracellular exosome
Show all GO termsFunction: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:5515; protein binding
GO:30145; manganese ion binding
GO:42802; identical protein binding
GO:4784; superoxide dismutase activity
GO:3677; DNA binding
GO:19825; oxygen binding
GO:19899; enzyme binding
Homologs of SOD2 in Model Organisms
- Caenorhabditis elegans
- sod-3
- Danio rerio
- sod2
- Drosophila melanogaster
- Sod2
- Mus musculus
- Sod2
- Rattus norvegicus
- Sod2
- Saccharomyces cerevisiae
- SOD2
- Schizosaccharomyces pombe
- SPBC16A3.14
In other databases
- GenAge model organism genes
- GenAge human genes
- This gene is present as SOD2
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as SOD2
- LongevityMap
- This gene is present as SOD2
External links
- OMIM
- 147460
- Ensembl
- ENSG00000112096
- Entrez Gene
- 6648
- UniGene
- 487046
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SOD2
- GeneCards
- SOD2