LongevityMap variant group
Entry Details
- Longevity Association
- Non-significant
- Population
- Caucasians
- Study Design
- Meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Longevity was defined as survival to age 90 years or older (n = 1,836); the comparison group comprised cohort members who died between the ages of 55 and 80 years (n = 1,955).
- Conclusions
- There were 273 single-nucleotide polymorphism (SNP) associations with p < .0001, but none reached significance after correcting for multiple testing
Variants (287)
- Gene summary:
- No gene (123)
- ASIC2 (3)
- CALB2 (3)
- CERS3 (18)
- CERS3-AS1 (2)
- CHIAP2 (1)
- CHST4 (1)
- CLEC3A (1)
- DIRAS2 (1)
- DRD2 (1)
- FASTKD3 (1)
- GNA14 (1)
- HOXD3 (1)
- KIAA0368 (1)
- LAPTM5 (2)
- LINC01446 (1)
- LINC01599 (5)
- LINC01901 (2)
- LINC01902 (1)
- LINC02331 (1)
- LOC100506929 (2)
- LOC102724929 (1)
- LOC105374430 (1)
- LOC105375670 (1)
- LOC105376360 (1)
- LOC105376823 (4)
- LOC105377356 (1)
- LOC105377519 (2)
- LOC107984390 (34)
- LOC107984897 (5)
- LOC107986150 (3)
- LOC107987056 (1)
- LOC643542 (7)
- LYPD6 (1)
- MACROD2 (3)
- MAN2B2 (1)
- MSC-AS1 (1)
- MSMO1 (2)
- MTA3 (2)
- MYO18B (7)
- NEO1 (5)
- OR2W3 (1)
- OR6Y1 (1)
- OTUD3 (2)
- PABPC4 (1)
- PARP1 (1)
- PPARGC1A (1)
- PTPRN2 (1)
- REM2 (1)
- RNASEH1 (2)
- RORB (1)
- RPS6KA2 (1)
- SCN9A (5)
- SH3PXD2B (2)
- SSBP3 (3)
- TMPRSS5 (3)
- XXYLT1 (3)
- ZNF19 (1)
- ZW10 (2)
No gene
ASIC2
Gene details
- HGNC symbol
- ASIC2
- Aliases
- ACCN; BNC1; MDEG; ACCN1; BNaC1; ASIC2a; hBNaC1
- Common name
- acid sensing ion channel subunit 2
- Description
- This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]
- Other longevity studies of this gene
- 3
- OMIM
- 601784
- Ensembl
- ENSG00000108684
- UniProt/Swiss-Prot
- ASIC2_HUMAN
- Entrez Gene
- 40
- UniGene
- 368417
- HapMap
- View on HapMap
Homologs in model organisms
CALB2
Gene details
- HGNC symbol
- CALB2
- Aliases
- CR; CAL2; CAB29
- Common name
- calbindin 2
- Description
- This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
- Other longevity studies of this gene
- 2
- OMIM
- 114051
- Ensembl
- ENSG00000172137
- UniProt/Swiss-Prot
- A0A140VK08_HUMAN
- Entrez Gene
- 794
- UniGene
- 106857
- HapMap
- View on HapMap
Homologs in model organisms
CERS3
Gene details
- HGNC symbol
- CERS3
- Aliases
- ARCI9; LASS3
- Common name
- ceramide synthase 3
- Description
- This gene is a member of the ceramide synthase family of genes. The ceramide synthase enzymes regulate sphingolipid synthesis by catalyzing the formation of ceramides from sphingoid base and acyl-coA substrates. This family member is involved in the synthesis of ceramides with ultra-long-chain acyl moieties (ULC-Cers), important to the epidermis in its role in creating a protective barrier from the environment. The protein encoded by this gene has also been implicated in modification of the lipid structures required for spermatogenesis. Mutations in this gene have been associated with male fertility defects, and epidermal defects, including ichthyosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
- Other longevity studies of this gene
- 17
- OMIM
- 615276
- Ensembl
- ENSG00000154227
- UniProt/Swiss-Prot
- CERS3_HUMAN
- Entrez Gene
- 204219
- UniGene
- 662371
- HapMap
- View on HapMap
Homologs in model organisms
CERS3-AS1
Gene details
- HGNC symbol
- CERS3-AS1
- Aliases
- Common name
- CERS3 antisense RNA 1
- Description
- Other longevity studies of this gene
- 1
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 102723320
- UniGene
- 416099
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
CHIAP2
Gene details
- HGNC symbol
- CHIAP2
- Aliases
- Common name
- chitinase, acidic pseudogene 2
- Description
- OMIM
- Ensembl
- ENSG00000203878
- UniProt/Swiss-Prot
- Entrez Gene
- 149620
- UniGene
- 736960
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
CHST4
Gene details
- HGNC symbol
- CHST4
- Aliases
- GST3; LSST; GlcNAc6ST2; HECGLCNAC6ST
- Common name
- carbohydrate sulfotransferase 4
- Description
- This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
- OMIM
- Ensembl
- ENSG00000140835
- UniProt/Swiss-Prot
- CHST4_HUMAN
- Entrez Gene
- 10164
- UniGene
- 251383
- HapMap
- View on HapMap
Homologs in model organisms
CLEC3A
Gene details
- HGNC symbol
- CLEC3A
- Aliases
- CLECSF1
- Common name
- C-type lectin domain family 3 member A
- Description
- OMIM
- 613588
- Ensembl
- ENSG00000166509
- UniProt/Swiss-Prot
- CLC3A_HUMAN
- Entrez Gene
- 10143
- UniGene
- 177936
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- clec-44
- Danio rerio
- LOC100330122
- Mus musculus
- Clec3a
- Rattus norvegicus
- Clec3a
DIRAS2
Gene details
- HGNC symbol
- DIRAS2
- Aliases
- Di-Ras2
- Common name
- DIRAS family GTPase 2
- Description
- DIRAS2 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]
- OMIM
- 607863
- Ensembl
- ENSG00000165023
- UniProt/Swiss-Prot
- DIRA2_HUMAN
- Entrez Gene
- 54769
- UniGene
- 165636
- HapMap
- View on HapMap
Homologs in model organisms
DRD2
Gene details
- HGNC symbol
- DRD2
- Aliases
- D2R; D2DR
- Common name
- dopamine receptor D2
- Description
- This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 2
- OMIM
- 126450
- Ensembl
- ENSG00000149295
- UniProt/Swiss-Prot
- A0A024R3C5_HUMAN
- Entrez Gene
- 1813
- UniGene
- 73893
- HapMap
- View on HapMap
Homologs in model organisms
FASTKD3
Gene details
- HGNC symbol
- FASTKD3
- Aliases
- Common name
- FAST kinase domains 3
- Description
- This gene encodes a member of a small family of Fas-activated serine/threonine kinase domain (FASTKD) containing proteins that share an amino terminal mitochondrial targeting domain and multiple carboxy terminal FAST domains as well as a putative RNA-binding RAP domain. The members of this family are ubiquitously expressed and are generally most abundant in mitochondria-enriched tissues such as heart, skeletal muscle and brown-adipose tissue. Some members of this protein family may play a role in apoptosis. The protein encoded by this gene interacts with components of the mitochondrial respiratory and translation networks. A pseudogene of this gene is also present on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
- OMIM
- Ensembl
- ENSG00000124279
- UniProt/Swiss-Prot
- FAKD3_HUMAN
- Entrez Gene
- 79072
- UniGene
- 653162
- HapMap
- View on HapMap
Homologs in model organisms
GNA14
Gene details
- HGNC symbol
- GNA14
- Aliases
- Common name
- G protein subunit alpha 14
- Description
- This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009]
- OMIM
- 604397
- Ensembl
- ENSG00000156049
- UniProt/Swiss-Prot
- GNA14_HUMAN
- Entrez Gene
- 9630
- UniGene
- 657795
- HapMap
- View on HapMap
Homologs in model organisms
HOXD3
Gene details
- HGNC symbol
- HOXD3
- Aliases
- HOX4; HOX1D; HOX4A; Hox-4.1
- Common name
- homeobox D3
- Description
- This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. [provided by RefSeq, Jul 2008]
- OMIM
- 142980
- Ensembl
- ENSG00000128652
- UniProt/Swiss-Prot
- HXD3_HUMAN
- Entrez Gene
- 3232
- UniGene
- 93574
- HapMap
- View on HapMap
Homologs in model organisms
KIAA0368
Gene details
- HGNC symbol
- KIAA0368
- Aliases
- ECM29
- Common name
- KIAA0368
- Description
- OMIM
- 616694
- Ensembl
- ENSG00000136813
- UniProt/Swiss-Prot
- ECM29_HUMAN
- Entrez Gene
- 23392
- UniGene
- 368255
- HapMap
- View on HapMap
Homologs in model organisms
LAPTM5
Gene details
- HGNC symbol
- LAPTM5
- Aliases
- CLAST6
- Common name
- lysosomal protein transmembrane 5
- Description
- This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq, Feb 2009]
- Other longevity studies of this gene
- 1
- OMIM
- 601476
- Ensembl
- ENSG00000162511
- UniProt/Swiss-Prot
- LAPM5_HUMAN
- Entrez Gene
- 7805
- UniGene
- 371021
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- GenAge microarray genes
- This gene is present as LAPTM5
LINC01446
Gene details
- HGNC symbol
- LINC01446
- Aliases
- GS1-179L18.1
- Common name
- long intergenic non-protein coding RNA 1446
- Description
- OMIM
- Ensembl
- ENSG00000205628
- UniProt/Swiss-Prot
- Entrez Gene
- 401337
- UniGene
- 531378
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LINC01599
Gene details
- HGNC symbol
- LINC01599
- Aliases
- C14orf183
- Common name
- long intergenic non-protein coding RNA 1599
- Description
- Other longevity studies of this gene
- 4
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 196913
- UniGene
- 406934
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LINC01901
Gene details
- HGNC symbol
- LINC01901
- Aliases
- Common name
- long intergenic non-protein coding RNA 1901
- Description
- Other longevity studies of this gene
- 1
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 105372080
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LINC01902
Gene details
- HGNC symbol
- LINC01902
- Aliases
- Common name
- long intergenic non-protein coding RNA 1902
- Description
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 105372079
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LINC02331
Gene details
- HGNC symbol
- LINC02331
- Aliases
- Common name
- long intergenic non-protein coding RNA 2331
- Description
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 105370503
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOC100506929
Gene details
- HGNC symbol
- LOC100506929
- Aliases
- Common name
- uncharacterized LOC100506929
- Description
- Other longevity studies of this gene
- 1
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 100506929
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOC102724929
Gene details
- HGNC symbol
- LOC102724929
- Aliases
- Common name
- uncharacterized LOC102724929
- Description
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 102724929
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOC105374430
Gene details
- HGNC symbol
- LOC105374430
- Aliases
- Common name
- uncharacterized LOC105374430
- Description
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 105374430
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOC105375670
Gene details
- HGNC symbol
- LOC105375670
- Aliases
- Common name
- uncharacterized LOC105375670
- Description
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 105375670
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOC105376360
Gene details
- HGNC symbol
- LOC105376360
- Aliases
- Common name
- uncharacterized LOC105376360
- Description
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 105376360
- UniGene
- 212226
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOC105376823
Gene details
- HGNC symbol
- LOC105376823
- Aliases
- Common name
- uncharacterized LOC105376823
- Description
- Other longevity studies of this gene
- 3
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 105376823
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOC105377356
Gene details
- HGNC symbol
- LOC105377356
- Aliases
- Common name
- uncharacterized LOC105377356
- Description
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 105377356
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOC105377519
Gene details
- HGNC symbol
- LOC105377519
- Aliases
- Common name
- uncharacterized LOC105377519
- Description
- Other longevity studies of this gene
- 1
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 105377519
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOC107984390
Gene details
- HGNC symbol
- LOC107984390
- Aliases
- Common name
- uncharacterized LOC107984390
- Description
- Other longevity studies of this gene
- 33
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 107984390
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOC107984897
Gene details
- HGNC symbol
- LOC107984897
- Aliases
- Common name
- uncharacterized LOC107984897
- Description
- Other longevity studies of this gene
- 4
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 107984897
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOC107986150
Gene details
- HGNC symbol
- LOC107986150
- Aliases
- Common name
- uncharacterized LOC107986150
- Description
- Other longevity studies of this gene
- 2
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 107986150
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOC107987056
Gene details
- HGNC symbol
- LOC107987056
- Aliases
- Common name
- uncharacterized LOC107987056
- Description
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 107987056
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOC643542
Gene details
- HGNC symbol
- LOC643542
- Aliases
- Common name
- uncharacterized LOC643542
- Description
- Other longevity studies of this gene
- 6
- OMIM
- Ensembl
- ENSG00000265533
- UniProt/Swiss-Prot
- Entrez Gene
- 643542
- UniGene
- 652901
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LYPD6
Gene details
- HGNC symbol
- LYPD6
- Aliases
- Common name
- LY6/PLAUR domain containing 6
- Description
- Members of the LY6 protein family (see SLURP1; MIM 606119), such as LYPD6, have at least one 80-amino acid LU domain that contains 10 conserved cysteines with a defined disulfide-bonding pattern (Zhang et al., 2010 [PubMed 19653121]).[supplied by OMIM, Apr 2010]
- OMIM
- 613359
- Ensembl
- ENSG00000187123
- UniProt/Swiss-Prot
- LYPD6_HUMAN
- Entrez Gene
- 130574
- UniGene
- 21929
- HapMap
- View on HapMap
Homologs in model organisms
MACROD2
Gene details
- HGNC symbol
- MACROD2
- Aliases
- C2orf133; C20orf133
- Common name
- MACRO domain containing 2
- Description
- Other longevity studies of this gene
- 2
- OMIM
- 611567
- Ensembl
- ENSG00000172264
- UniProt/Swiss-Prot
- MACD2_HUMAN
- Entrez Gene
- 140733
- UniGene
- 661576
- HapMap
- View on HapMap
Homologs in model organisms
MAN2B2
Gene details
- HGNC symbol
- MAN2B2
- Aliases
- Common name
- mannosidase alpha class 2B member 2
- Description
- OMIM
- Ensembl
- ENSG00000013288
- UniProt/Swiss-Prot
- B7Z754_HUMAN
- Entrez Gene
- 23324
- UniGene
- 188464
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- CellAge gene expression
- This gene is present as MAN2B2
MSC-AS1
Gene details
- HGNC symbol
- MSC-AS1
- Aliases
- Common name
- MSC antisense RNA 1
- Description
- OMIM
- Ensembl
- ENSG00000235531
- UniProt/Swiss-Prot
- Entrez Gene
- 100132891
- UniGene
- 137674
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
MSMO1
Gene details
- HGNC symbol
- MSMO1
- Aliases
- DESP4; ERG25; MCCPD; SC4MOL
- Common name
- methylsterol monooxygenase 1
- Description
- Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 1
- OMIM
- 607545
- Ensembl
- ENSG00000052802
- UniProt/Swiss-Prot
- MSMO1_HUMAN
- Entrez Gene
- 6307
- UniGene
- 105269
- HapMap
- View on HapMap
Homologs in model organisms
MTA3
Gene details
- HGNC symbol
- MTA3
- Aliases
- Common name
- metastasis associated 1 family member 3
- Description
- Other longevity studies of this gene
- 1
- OMIM
- 609050
- Ensembl
- ENSG00000057935
- UniProt/Swiss-Prot
- D6W5A2_HUMAN
- Entrez Gene
- 57504
- UniGene
- 435413
- HapMap
- View on HapMap
Homologs in model organisms
MYO18B
Gene details
- HGNC symbol
- MYO18B
- Aliases
- KFS4
- Common name
- myosin XVIIIB
- Description
- The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 6
- OMIM
- 607295
- Ensembl
- ENSG00000133454
- UniProt/Swiss-Prot
- A0A075B6F5_HUMAN
- Entrez Gene
- 84700
- UniGene
- 417959
- HapMap
- View on HapMap
Homologs in model organisms
NEO1
Gene details
- HGNC symbol
- NEO1
- Aliases
- NGN; IGDCC2; NTN1R2
- Common name
- neogenin 1
- Description
- This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
- Other longevity studies of this gene
- 4
- OMIM
- 601907
- Ensembl
- ENSG00000067141
- UniProt/Swiss-Prot
- NEO1_HUMAN
- Entrez Gene
- 4756
- UniGene
- 388613
- HapMap
- View on HapMap
Homologs in model organisms
OR2W3
Gene details
- HGNC symbol
- OR2W3
- Aliases
- OR2W3P; OR2W8P; OST718
- Common name
- olfactory receptor family 2 subfamily W member 3
- Description
- Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
- OMIM
- 616729
- Ensembl
- ENSG00000238243
- UniProt/Swiss-Prot
- OR2W3_HUMAN
- Entrez Gene
- 343171
- UniGene
- 269151
- HapMap
- View on HapMap
Homologs in model organisms
OR6Y1
Gene details
- HGNC symbol
- OR6Y1
- Aliases
- OR6Y2; OR1-11
- Common name
- olfactory receptor family 6 subfamily Y member 1
- Description
- Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
- OMIM
- Ensembl
- ENSG00000197532
- UniProt/Swiss-Prot
- OR6Y1_HUMAN
- Entrez Gene
- 391112
- UniGene
- 553780
- HapMap
- View on HapMap
Homologs in model organisms
OTUD3
Gene details
- HGNC symbol
- OTUD3
- Aliases
- DUBA4
- Common name
- OTU deubiquitinase 3
- Description
- Other longevity studies of this gene
- 1
- OMIM
- 611758
- Ensembl
- ENSG00000169914
- UniProt/Swiss-Prot
- OTUD3_HUMAN
- Entrez Gene
- 23252
- UniGene
- 374987
- HapMap
- View on HapMap
Homologs in model organisms
PABPC4
Gene details
- HGNC symbol
- PABPC4
- Aliases
- APP1; APP-1; PABP4; iPABP
- Common name
- poly(A) binding protein cytoplasmic 4
- Description
- Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
- OMIM
- 603407
- Ensembl
- ENSG00000090621
- UniProt/Swiss-Prot
- PABP4_HUMAN
- Entrez Gene
- 8761
- UniGene
- 169900
- HapMap
- View on HapMap
Homologs in model organisms
PARP1
Gene details
- HGNC symbol
- PARP1
- Aliases
- PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT; 1; pADPRT-1
- Common name
- poly(ADP-ribose) polymerase 1
- Description
- This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 15
- OMIM
- 173870
- Ensembl
- ENSG00000143799
- UniProt/Swiss-Prot
- A0A024R3T8_HUMAN
- Entrez Gene
- 142
- UniGene
- 177766
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- pme-1
- Danio rerio
- parp1
- Drosophila melanogaster
- Parp
- Mus musculus
- Parp1
- Rattus norvegicus
- Parp1
In other databases
PPARGC1A
Gene details
- HGNC symbol
- PPARGC1A
- Aliases
- LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1alpha; PGC-1(alpha)
- Common name
- PPARG coactivator 1 alpha
- Description
- The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 7
- OMIM
- 604517
- Ensembl
- ENSG00000109819
- UniProt/Swiss-Prot
- A0A024R9Q9_HUMAN
- Entrez Gene
- 10891
- UniGene
- 527078
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
PTPRN2
Gene details
- HGNC symbol
- PTPRN2
- Aliases
- IAR; ICAAR; PTPRP; IA-2beta; R-PTP-N2
- Common name
- protein tyrosine phosphatase, receptor type N2
- Description
- This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
- OMIM
- 601698
- Ensembl
- ENSG00000155093
- UniProt/Swiss-Prot
- E7EM83_HUMAN
- Entrez Gene
- 5799
- UniGene
- 490789
- HapMap
- View on HapMap
Homologs in model organisms
REM2
Gene details
- HGNC symbol
- REM2
- Aliases
- Common name
- RRAD and GEM like GTPase 2
- Description
- OMIM
- 616955
- Ensembl
- ENSG00000139890
- UniProt/Swiss-Prot
- REM2_HUMAN
- Entrez Gene
- 161253
- UniGene
- 444911
- HapMap
- View on HapMap
Homologs in model organisms
RNASEH1
Gene details
- HGNC symbol
- RNASEH1
- Aliases
- RNH1; H1RNA; PEOB2
- Common name
- ribonuclease H1
- Description
- This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and is necessary for DNA replication and repair. This enzyme is present in both mitochondria and nuclei, which are resulted from translation of a single mRNA with two in-frame initiation start codons. The use of the first start codon produces the mitochondrial isoform and the use of the second start codon produces the nuclear isoform. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF) which overlaps the first initiation start codon in human. An alternately spliced transcript variant has been found which encodes a shorter isoform. This gene has three pseudogenes; two of them are at different locations of chromosome 17 and one of them is on chromosome 1q32.2. [provided by RefSeq, Sep 2014]
- Other longevity studies of this gene
- 1
- OMIM
- 604123
- Ensembl
- ENSG00000171865
- UniProt/Swiss-Prot
- B3KUD4_HUMAN
- Entrez Gene
- 246243
- UniGene
- 568006
- HapMap
- View on HapMap
Homologs in model organisms
RORB
Gene details
- HGNC symbol
- RORB
- Aliases
- RZRB; NR1F2; ROR-BETA; RZR-BETA; bA133M9.1
- Common name
- RAR related orphan receptor B
- Description
- The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]
- OMIM
- 601972
- Ensembl
- ENSG00000198963
- UniProt/Swiss-Prot
- Q58EY0_HUMAN
- Entrez Gene
- 6096
- UniGene
- 494178
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
RPS6KA2
Gene details
- HGNC symbol
- RPS6KA2
- Aliases
- RSK; HU-2; RSK3; p90RSK2; p90-RSK3; pp90RSK3; MAPKAPK1C; S6K-alpha; S6K-alpha2
- Common name
- ribosomal protein S6 kinase A2
- Description
- This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]
- OMIM
- 601685
- Ensembl
- ENSG00000071242
- UniProt/Swiss-Prot
- B7Z3B5_HUMAN
- Entrez Gene
- 6196
- UniGene
- 655277
- HapMap
- View on HapMap
Homologs in model organisms
SCN9A
Gene details
- HGNC symbol
- SCN9A
- Aliases
- PN1; ETHA; NENA; SFNP; FEB3B; NE-NA; GEFSP7; HSAN2D; Nav1.7
- Common name
- sodium voltage-gated channel alpha subunit 9
- Description
- This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009]
- Other longevity studies of this gene
- 4
- OMIM
- 603415
- Ensembl
- ENSG00000169432
- UniProt/Swiss-Prot
- SCN9A_HUMAN
- Entrez Gene
- 6335
- UniGene
- 439145
- HapMap
- View on HapMap
Homologs in model organisms
SH3PXD2B
Gene details
- HGNC symbol
- SH3PXD2B
- Aliases
- FTHS; HOFI; TKS4; TSK4; FAD49; KIAA1295
- Common name
- SH3 and PX domains 2B
- Description
- This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome (FTHS), and also Borrone Dermato-Cardio-Skeletal (BDCS) syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
- Other longevity studies of this gene
- 1
- OMIM
- 613293
- Ensembl
- ENSG00000174705
- UniProt/Swiss-Prot
- G3V144_HUMAN
- Entrez Gene
- 285590
- UniGene
- 285666
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- sh3pxd2b
- Mus musculus
- Sh3pxd2b
- Rattus norvegicus
- RGD1309926
SSBP3
Gene details
- HGNC symbol
- SSBP3
- Aliases
- CSDP; SSDP; SSDP1
- Common name
- single stranded DNA binding protein 3
- Description
- Other longevity studies of this gene
- 2
- OMIM
- 607390
- Ensembl
- ENSG00000157216
- UniProt/Swiss-Prot
- Q9NW25_HUMAN
- Entrez Gene
- 23648
- UniGene
- 476706
- HapMap
- View on HapMap
Homologs in model organisms
TMPRSS5
Gene details
- HGNC symbol
- TMPRSS5
- Aliases
- SPINESIN
- Common name
- transmembrane protease, serine 5
- Description
- This gene encodes a protein that belongs to the serine protease family. Serine proteases are known to be involved in many physiological and pathological processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
- Other longevity studies of this gene
- 2
- OMIM
- 606751
- Ensembl
- ENSG00000166682
- UniProt/Swiss-Prot
- B7Z247_HUMAN
- Entrez Gene
- 80975
- UniGene
- 46720
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- uncharacterized_F1QP
- Drosophila melanogaster
- CG4914
- Mus musculus
- Tmprss5
- Rattus norvegicus
- Tmprss5
XXYLT1
Gene details
- HGNC symbol
- XXYLT1
- Aliases
- C3orf21
- Common name
- xyloside xylosyltransferase 1
- Description
- Other longevity studies of this gene
- 2
- OMIM
- 614552
- Ensembl
- ENSG00000173950
- UniProt/Swiss-Prot
- A0A140T9D0_HUMAN
- Entrez Gene
- 152002
- UniGene
- 478741
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- LOC100334669
- Drosophila melanogaster
- CG11388-RA
- Mus musculus
- Xxylt1
- Rattus norvegicus
- Xxylt1
ZNF19
Gene details
- HGNC symbol
- ZNF19
- Aliases
- KOX12
- Common name
- zinc finger protein 19
- Description
- The protein encoded by this gene contains a zinc finger, a nucleic acid-binding domain present in many transcription factors. This gene is located in a region next to ZNF23, a gene also encoding a zinc finger protein, on chromosome 16. [provided by RefSeq, Jul 2008]
- OMIM
- 194525
- Ensembl
- ENSG00000157429
- UniProt/Swiss-Prot
- ZNF19_HUMAN
- Entrez Gene
- 7567
- UniGene
- 660076
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
ZW10
Gene details
- HGNC symbol
- ZW10
- Aliases
- HZW10; KNTC1AP
- Common name
- zw10 kinetochore protein
- Description
- This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]
- Other longevity studies of this gene
- 1
- OMIM
- 603954
- Ensembl
- ENSG00000086827
- UniProt/Swiss-Prot
- ZW10_HUMAN
- Entrez Gene
- 9183
- UniGene
- 503886
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- czw-1
- Danio rerio
- zw10
- Drosophila melanogaster
- mit(1)15
- Mus musculus
- Zw10
- Rattus norvegicus
- Zw10
In other databases
- CellAge gene expression
- This gene is present as ZW10