LongevityMap variant group
Entry Details
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).
- Conclusions
- Thirty-two SNPs previously associated with longevity were not associated with longevity in this study
Variants (32)
- Gene summary:
- No gene (7)
- ANKRD55 (1)
- CELSR1 (1)
- CRTAC1 (1)
- CTNNA3 (1)
- FAM98B (1)
- FGD5 (1)
- GORASP2 (1)
- HLA-DPB2 (1)
- IGF2BP1 (1)
- IL7 (1)
- KIF26B (1)
- LINC01088 (1)
- LOC101928226 (1)
- LOC105372507 (1)
- LOC105373938 (1)
- LOC105375856 (1)
- MAVS (1)
- MS4A15 (1)
- MSI2 (1)
- PLCB3 (1)
- RAPGEF4 (1)
- STX8 (1)
- SYBU (1)
- TCF19 (1)
- ZFAT (1)
No gene
ANKRD55
Gene details
- HGNC symbol
- ANKRD55
- Aliases
- Common name
- ankyrin repeat domain 55
- Description
- OMIM
- 615189
- Ensembl
- ENSG00000164512
- UniProt/Swiss-Prot
- ANR55_HUMAN
- Entrez Gene
- 79722
- UniGene
- 436214
- HapMap
- View on HapMap
Homologs in model organisms
CELSR1
Gene details
- HGNC symbol
- CELSR1
- Aliases
- ME2; FMI2; CDHF9; HFMI2; ADGRC1
- Common name
- cadherin EGF LAG seven-pass G-type receptor 1
- Description
- The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008]
- OMIM
- 604523
- Ensembl
- ENSG00000075275
- UniProt/Swiss-Prot
- CELR1_HUMAN
- Entrez Gene
- 9620
- UniGene
- 252387
- HapMap
- View on HapMap
Homologs in model organisms
CRTAC1
Gene details
- HGNC symbol
- CRTAC1
- Aliases
- ASPIC; ASPIC1; CEP-68
- Common name
- cartilage acidic protein 1
- Description
- This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
- OMIM
- 606276
- Ensembl
- ENSG00000095713
- UniProt/Swiss-Prot
- CRAC1_HUMAN
- Entrez Gene
- 55118
- UniGene
- 500736
- HapMap
- View on HapMap
Homologs in model organisms
CTNNA3
Gene details
- HGNC symbol
- CTNNA3
- Aliases
- VR22; ARVD13
- Common name
- catenin alpha 3
- Description
- This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
- Other longevity studies of this gene
- 1
- OMIM
- 607667
- Ensembl
- ENSG00000183230
- UniProt/Swiss-Prot
- A8K141_HUMAN
- Entrez Gene
- 29119
- UniGene
- 21375
- HapMap
- View on HapMap
Homologs in model organisms
FAM98B
Gene details
- HGNC symbol
- FAM98B
- Aliases
- Common name
- family with sequence similarity 98 member B
- Description
- OMIM
- 616142
- Ensembl
- ENSG00000171262
- UniProt/Swiss-Prot
- FA98B_HUMAN
- Entrez Gene
- 283742
- UniGene
- 6799
- HapMap
- View on HapMap
Homologs in model organisms
FGD5
Gene details
- HGNC symbol
- FGD5
- Aliases
- ZFYVE23
- Common name
- FYVE, RhoGEF and PH domain containing 5
- Description
- OMIM
- 614788
- Ensembl
- ENSG00000154783
- UniProt/Swiss-Prot
- B7ZM68_HUMAN
- Entrez Gene
- 152273
- UniGene
- 412406
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- LOC100151562
- Mus musculus
- Fgd5
- Rattus norvegicus
- Fgd5
GORASP2
Gene details
- HGNC symbol
- GORASP2
- Aliases
- p59; GRS2; GOLPH6; GRASP55
- Common name
- golgi reassembly stacking protein 2
- Description
- This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
- OMIM
- 608693
- Ensembl
- ENSG00000115806
- UniProt/Swiss-Prot
- GORS2_HUMAN
- Entrez Gene
- 26003
- UniGene
- 431317
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- CELE_Y42H9AR.1
- Danio rerio
- gorasp2
- Drosophila melanogaster
- Grasp65
- Mus musculus
- Gorasp2
- Rattus norvegicus
- Gorasp2
- Schizosaccharomyces pombe
- SPAC1D4.02c
HLA-DPB2
Gene details
- HGNC symbol
- HLA-DPB2
- Aliases
- DP2B; DPB2; DPbeta2; HLA-DP2B
- Common name
- major histocompatibility complex, class II, DP beta 2 (pseudogene)
- Description
- OMIM
- Ensembl
- ENSG00000224557
- UniProt/Swiss-Prot
- Entrez Gene
- 3116
- UniGene
- 665450
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
IGF2BP1
Gene details
- HGNC symbol
- IGF2BP1
- Aliases
- IMP1; ZBP1; CRDBP; IMP-1; CRD-BP; VICKZ1
- Common name
- insulin like growth factor 2 mRNA binding protein 1
- Description
- This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
- OMIM
- 608288
- Ensembl
- ENSG00000159217
- UniProt/Swiss-Prot
- IF2B1_HUMAN
- Entrez Gene
- 10642
- UniGene
- 144936
- HapMap
- View on HapMap
Homologs in model organisms
IL7
Gene details
- HGNC symbol
- IL7
- Aliases
- IL-7
- Common name
- interleukin 7
- Description
- The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]
- OMIM
- 146660
- Ensembl
- ENSG00000104432
- UniProt/Swiss-Prot
- A0A0A0MTG5_HUMAN
- Entrez Gene
- 3574
- UniGene
- 591873
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- GenAge human genes
- This gene is present as IL7
KIF26B
Gene details
- HGNC symbol
- KIF26B
- Aliases
- Common name
- kinesin family member 26B
- Description
- The protein encoded by this gene is an intracellular motor protein thought to transport organelles along microtubules. The encoded protein is required for kidney development. Elevated levels of this protein have been found in some breast and colorectal cancers. [provided by RefSeq, Mar 2017]
- OMIM
- 614026
- Ensembl
- ENSG00000162849
- UniProt/Swiss-Prot
- B7WPD9_HUMAN
- Entrez Gene
- 55083
- UniGene
- 143134
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- uncharacterized_E7FD
- Mus musculus
- Kif26b
- Rattus norvegicus
- Kif26b
LINC01088
Gene details
- HGNC symbol
- LINC01088
- Aliases
- Common name
- long intergenic non-protein coding RNA 1088
- Description
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 100505875
- UniGene
- 480055
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOC101928226
Gene details
- HGNC symbol
- LOC101928226
- Aliases
- Common name
- uncharacterized LOC101928226
- Description
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 101928226
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOC105372507
Gene details
- HGNC symbol
- LOC105372507
- Aliases
- Common name
- uncharacterized LOC105372507
- Description
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 105372507
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOC105373938
Gene details
- HGNC symbol
- LOC105373938
- Aliases
- Common name
- uncharacterized LOC105373938
- Description
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 105373938
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOC105375856
Gene details
- HGNC symbol
- LOC105375856
- Aliases
- Common name
- uncharacterized LOC105375856
- Description
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 105375856
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
MAVS
Gene details
- HGNC symbol
- MAVS
- Aliases
- IPS1; VISA; IPS-1; CARDIF
- Common name
- mitochondrial antiviral signaling protein
- Description
- This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
- OMIM
- 609676
- Ensembl
- ENSG00000088888
- UniProt/Swiss-Prot
- MAVS_HUMAN
- Entrez Gene
- 57506
- UniGene
- 570362
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- CellAge
- This gene is present as MAVS
MS4A15
Gene details
- HGNC symbol
- MS4A15
- Aliases
- Common name
- membrane spanning 4-domains A15
- Description
- OMIM
- Ensembl
- ENSG00000166961
- UniProt/Swiss-Prot
- B4DTI9_HUMAN
- Entrez Gene
- 219995
- UniGene
- 207465
- HapMap
- View on HapMap
Homologs in model organisms
MSI2
Gene details
- HGNC symbol
- MSI2
- Aliases
- MSI2H
- Common name
- musashi RNA binding protein 2
- Description
- This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. [provided by RefSeq, Apr 2016]
- OMIM
- 607897
- Ensembl
- ENSG00000153944
- UniProt/Swiss-Prot
- B4DHE8_HUMAN
- Entrez Gene
- 124540
- UniGene
- 658922
- HapMap
- View on HapMap
Homologs in model organisms
PLCB3
Gene details
- HGNC symbol
- PLCB3
- Aliases
- Common name
- phospholipase C beta 3
- Description
- This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
- OMIM
- 600230
- Ensembl
- ENSG00000149782
- UniProt/Swiss-Prot
- PLCB3_HUMAN
- Entrez Gene
- 5331
- UniGene
- 523761
- HapMap
- View on HapMap
Homologs in model organisms
RAPGEF4
Gene details
- HGNC symbol
- RAPGEF4
- Aliases
- EPAC; CGEF2; EPAC2; EPAC; 2; Nbla00496; CAMP-GEFII
- Common name
- Rap guanine nucleotide exchange factor 4
- Description
- OMIM
- 606058
- Ensembl
- ENSG00000091428
- UniProt/Swiss-Prot
- B7Z278_HUMAN
- Entrez Gene
- 11069
- UniGene
- 470646
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- CellAge
- This gene is present as RAPGEF4
STX8
Gene details
- HGNC symbol
- STX8
- Aliases
- CARB
- Common name
- syntaxin 8
- Description
- The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
- OMIM
- 604203
- Ensembl
- ENSG00000170310
- UniProt/Swiss-Prot
- STX8_HUMAN
- Entrez Gene
- 9482
- UniGene
- 431109
- HapMap
- View on HapMap
Homologs in model organisms
SYBU
Gene details
- HGNC symbol
- SYBU
- Aliases
- OCSYN; SNPHL; GOLSYN
- Common name
- syntabulin
- Description
- Syntabulin/GOLSYN is part of a kinesin motor-adaptor complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development (Cai et al., 2007 [PubMed 17611281]).[supplied by OMIM, Mar 2008]
- OMIM
- 611568
- Ensembl
- ENSG00000147642
- UniProt/Swiss-Prot
- B7Z4D2_HUMAN
- Entrez Gene
- 55638
- UniGene
- 390738
- HapMap
- View on HapMap
Homologs in model organisms
TCF19
Gene details
- HGNC symbol
- TCF19
- Aliases
- SC1; TCF-19
- Common name
- transcription factor 19
- Description
- This gene encodes a protein that contains a PHD-type zinc finger domain and likely functions as a transcription factor. The encoded protein plays a role proliferation and apoptosis of pancreatic beta cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
- OMIM
- 600912
- Ensembl
- ENSG00000137310
- UniProt/Swiss-Prot
- TCF19_HUMAN
- Entrez Gene
- 6941
- UniGene
- 584807
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- CellAge gene expression
- This gene is present as TCF19
ZFAT
Gene details
- HGNC symbol
- ZFAT
- Aliases
- AITD3; ZFAT1; ZNF406
- Common name
- zinc finger and AT-hook domain containing
- Description
- This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
- OMIM
- 610931
- Ensembl
- ENSG00000066827
- UniProt/Swiss-Prot
- B7Z6H1_HUMAN
- Entrez Gene
- 57623
- UniGene
- 446172
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as mep-1