Cell Senescence Entries for RAPGEF4

Cell Types
Endometrial stromal
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Kusama et al. (2014) The role of exchange protein directly activated by cyclic AMP 2-mediated calreticulin expression in the decidualization of human endometrial stromal cells. Endocrinology 155(1)240-8 (PubMed)

RAPGEF4 Gene Information

HGNC symbol
RAPGEF4 
Aliases
cAMP-GEFII; CGEF2 
Common name
Rap guanine nucleotide exchange factor 4 
Entrez Id
11069
Description

RAPGEF4 Ontologies

Gene Ontology
Process: GO:35556; intracellular signal transduction
GO:7264; small GTPase mediated signal transduction
GO:6887; exocytosis
GO:7186; G protein-coupled receptor signaling pathway
GO:43547; positive regulation of GTPase activity
GO:7265; Ras protein signal transduction
GO:2250; adaptive immune response
GO:7188; adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:7189; adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:17156; calcium-ion regulated exocytosis
GO:17157; regulation of exocytosis
And 5 more GO terms
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5886; plasma membrane
GO:5829; cytosol
GO:98686; hippocampal mossy fiber to CA3 synapse
Function: GO:166; nucleotide binding
GO:5085; guanyl-nucleotide exchange factor activity
GO:5515; protein binding
GO:30552; cAMP binding
GO:31267; small GTPase binding
Show all GO terms

Homologs of RAPGEF4 in Model Organisms

Danio rerio
rapgef4
Drosophila melanogaster
Epac
Mus musculus
Rapgef4

In other databases

LongevityMap

External links

OMIM
606058
Ensembl
ENSG00000091428
Entrez Gene
11069
UniGene
470646
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RAPGEF4
GeneCards
RAPGEF4