GenAge entry for FOXO1 (Homo sapiens)

Gene name (HAGRID: 124)

HGNC symbol: FOXO1
Aliases: FKH1; FKHR; FOXO1A
Common name: forkhead box O1

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model

Description

A transcription factor of the Fox family, FOXO1 is important in development [802]. It also appears to regulate apoptotic signals.

A homologue of FOXO1A, daf-16, has been associated with ageing in roundworms [628], and overexpression of another homologue, dFOXO, in adult fat body of fruit flies increased longevity in females [1238]. Mice overexpressing FOXO1 in skeletal muscle weighed less than controls and had a reduced skeletal muscle mass, suggesting that FOXO1 could play a role in the age-related decline in muscle mass [1467]. Results from mice also suggest that FOXO1 could be involved in type 2 diabetes [630]. Although at present there is no evidence directly linking FOXO1 to human ageing, it remains a putative player in the human ageing process.

Cytogenetic information

Cytogenetic band: 13q14.1
Location: 40,555,664 bp to 40,666,597 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001568; blood vessel development
GO:0001659; temperature homeostasis
GO:0001678; cellular glucose homeostasis
GO:0006351; transcription, DNA-templated
GO:0006473; protein acetylation
GO:0006914; autophagy
GO:0006915; apoptotic process
GO:0006974; cellular response to DNA damage stimulus
GO:0008286; insulin receptor signaling pathway
GO:0009267; cellular response to starvation

And 28 more GO terms

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol

Function:

GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0000989; transcription factor activity, transcription factor binding
GO:0001078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001223; transcription coactivator binding
GO:0003682; chromatin binding
GO:0005515; protein binding
GO:0008013; beta-catenin binding
GO:0031625; ubiquitin protein ligase binding
GO:0043565; sequence-specific DNA binding
GO:0051721; protein phosphatase 2A binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: AKT1, PARP1, CREBBP, CEBPB, EP300, PML, GSK3B, AR, RB1, FOXO1, SIRT1, YWHAZ, FOXO4, MDM2, ESR1, STUB1, CDKN1A
STRING interaction network

Retrieve sequences for FOXO1

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: foxo1b
Mus musculus: Foxo1
Rattus norvegicus: Foxo1

In other databases

LongevityMap

This gene is present as FOXO1

CellAge

This gene is present as FOXO1