GenAge entry for GPX1 (Homo sapiens)

Gene name (HAGRID: 153)

HGNC symbol
GPX1 
Aliases
 
Common name
glutathione peroxidase 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

Mostly present in erythrocytes, GPX1 protects from oxidative damage. Changes in GPX1 have been reported in mice during ageing and due to caloric restriction [243], but there is no direct evidence linking GPX1 to ageing. Mice without GPX1 are more susceptibility to oxidative stress, but do not show signs of premature ageing [741], except for cataracts [742]. Overexpression of GPX1 in mice results in insulin (INS) resistance and obesity [1066]. Results from transgenic mice overexpressing GPX1 in the heart suggest GPX1 could be beneficial to prevent cardiac failure [1711]. Its role, if any, in human ageing remains to be determined.

Cytogenetic information

Cytogenetic band
3p21.3
Location
49,357,176 bp to 49,358,358 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000302; response to reactive oxygen species
GO:0001659; temperature homeostasis
GO:0001885; endothelial cell development
GO:0002862; negative regulation of inflammatory response to antigenic stimulus
GO:0006195; purine nucleotide catabolic process
GO:0006641; triglyceride metabolic process
GO:0006749; glutathione metabolic process
GO:0007605; sensory perception of sound
GO:0008631; intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009410; response to xenobiotic stimulus
GO:0009609; response to symbiotic bacterium
GO:0009650; UV protection
GO:0010269; response to selenium ion
GO:0010332; response to gamma radiation
GO:0018158; protein oxidation
GO:0019372; lipoxygenase pathway
GO:0033194; response to hydroperoxide
GO:0033599; regulation of mammary gland epithelial cell proliferation
GO:0034599; cellular response to oxidative stress
GO:0040029; regulation of gene expression, epigenetic
GO:0042311; vasodilation
GO:0042542; response to hydrogen peroxide
GO:0042744; hydrogen peroxide catabolic process
GO:0043154; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043403; skeletal muscle tissue regeneration
GO:0043523; regulation of neuron apoptotic process
GO:0043534; blood vessel endothelial cell migration
GO:0045444; fat cell differentiation
GO:0045454; cell redox homeostasis
GO:0048741; skeletal muscle fiber development
GO:0051450; myoblast proliferation
GO:0051702; interaction with symbiont
GO:0051897; positive regulation of protein kinase B signaling
GO:0060047; heart contraction
GO:0060055; angiogenesis involved in wound healing
GO:0061136; regulation of proteasomal protein catabolic process
GO:0090201; negative regulation of release of cytochrome c from mitochondria
GO:0098869; cellular oxidant detoxification
GO:1902042; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902176; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902905; positive regulation of supramolecular fiber organization
Cellular component: GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005759; mitochondrial matrix
GO:0005829; cytosol
GO:0070062; extracellular exosome
GO:0097413; Lewy body
Function: GO:0004602; glutathione peroxidase activity
GO:0017124; SH3 domain binding
Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TXN, ABL1
STRING interaction network
Protein-Protein network diagram for GPX1

Retrieve sequences for GPX1

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
gpx-4
Danio rerio
gpx1b
Mus musculus
Gpx1
Rattus norvegicus
Gpx1

In other databases

LongevityMap
  • This gene is present as GPX1

Selected references

External links

EPD
HS_GPX1
ORF Accession
NM_000581
CDS Accession
NP_000572
OMIM
138320
HPRD
11749
Ensembl
GPX1
UniProt/Swiss-Prot
GPX1_HUMAN
GeneCards
GPX1
Entrez Gene
2876
UniGene
76686
GenAtlas
GPX1
Internet
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