GenAge entry for HTRA2 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 294)

HGNC symbol: HTRA2
Aliases: OMI; PARK13; PRSS25
Common name: HtrA serine peptidase 2

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: HTRA2 is a serine protease involved in apoptosis. Mice mutant for in Htra2 develop neurodegeneration 30–40 days after birth. However, also expressing human HTRA2 in the central nervous system rescues mice from the neurodegeneration and prevents premature death; the mice then go on to develop signs of premature ageing, including premature weight loss, hair loss, reduced fertility and kyphosis [3254]. These results suggest that HTRA2 might play a role in ageing beyond neurodegeneration, though further studies are necessary to establish this.

Cytogenetic information

Cytogenetic band: 2p12
Location: 74,529,405 bp to 74,533,556 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006508; proteolysis
GO:0006672; ceramide metabolic process
GO:0007005; mitochondrion organization
GO:0007568; aging
GO:0007628; adult walking behavior
GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009635; response to herbicide
GO:0010822; positive regulation of mitochondrion organization
GO:0010942; positive regulation of cell death
GO:0016540; protein autoprocessing
GO:0019742; pentacyclic triterpenoid metabolic process

And 21 more GO terms

Cellular component:	GO:0000785; chromatin GO:0005634; nucleus GO:0005739; mitochondrion GO:0005758; mitochondrial intermembrane space GO:0005783; endoplasmic reticulum GO:0005789; endoplasmic reticulum membrane GO:0005829; cytosol GO:0005856; cytoskeleton GO:0009898; cytoplasmic side of plasma membrane GO:0016020; membrane GO:0031966; mitochondrial membrane
	And 2 more GO terms

Function:

GO:0004252; serine-type endopeptidase activity
GO:0005515; protein binding
GO:0008233; peptidase activity
GO:0008236; serine-type peptidase activity
GO:0051082; unfolded protein binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: VCP, MAPK14, MAPK3, EEF1A1, CDK1, HTRA2
STRING interaction network

Retrieve sequences for HTRA2

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: LOC793110
Mus musculus: Htra2
Rattus norvegicus: Htra2

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Htra2