GenAge entry for MAPK3 (Homo sapiens)

Gene name (HAGRID: 175)

HGNC symbol: MAPK3
Aliases: ERK1; p44mapk; p44erk1; PRKM3
Common name: mitogen-activated protein kinase 3

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: Also called ERK1, MAPK3 is involved in stress response signalling and maybe in cell cycle control. MAPK3-null mice are viable and fertile but have defective thymocyte maturation [788]. Changes in stress response have been reported during murine ageing that could be a result of changes in MAPK3 [346]. The relevance of MAPK3 to human ageing remains undetermined.

Cytogenetic information

Cytogenetic band: 16p11.2
Location: 30,114,105 bp to 30,123,309 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000165; MAPK cascade
GO:0000187; activation of MAPK activity
GO:0000189; MAPK import into nucleus
GO:0001934; positive regulation of protein phosphorylation
GO:0006361; transcription initiation from RNA polymerase I promoter
GO:0006461; protein complex assembly
GO:0006468; protein phosphorylation
GO:0006915; apoptotic process
GO:0006975; DNA damage induced protein phosphorylation
GO:0007049; cell cycle
GO:0007411; axon guidance

And 49 more GO terms

Cellular component:	GO:0005634; nucleus GO:0005635; nuclear envelope GO:0005654; nucleoplasm GO:0005739; mitochondrion GO:0005769; early endosome GO:0005770; late endosome GO:0005794; Golgi apparatus GO:0005829; cytosol GO:0005856; cytoskeleton GO:0005901; caveola GO:0005925; focal adhesion
	And 5 more GO terms

Function:

GO:0001784; phosphotyrosine binding
GO:0004674; protein serine/threonine kinase activity
GO:0004707; MAP kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016301; kinase activity
GO:0019902; phosphatase binding
GO:0097110; scaffold protein binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, MYC, INSR, RET, BRCA1, CREBBP, VCP, PML, HTT, SNCG, MAPK14, SP1, JUN, MAPK3, ATF2, PTGS2, SIRT6, CHEK2, TP53BP1, HTRA2
STRING interaction network

Retrieve sequences for MAPK3

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: mpk-1
Drosophila melanogaster: rl
Mus musculus: Mapk3
Rattus norvegicus: Mapk3
Saccharomyces cerevisiae: KSS1
Schizosaccharomyces pombe: spk1

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as KSS1
A homolog of this gene for Caenorhabditis elegans is present as mpk-1

LongevityMap

This gene is present as MAPK3