GenAge entry for PDGFRB (Homo sapiens)
Gene name (HAGRID: 51)
- HGNC symbol
- PDGFRB
- Aliases
- JTK12; CD140b; PDGFR1; PDGFR
- Common name
- platelet-derived growth factor receptor, beta polypeptide
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
PDGFRB binds PDGFB and thus may be related to age-related changes in the heart [363]. PDGFRB is also an important player in development [379].
Cytogenetic information
- Cytogenetic band
- 5q33.1
- Location
- 150,113,839 bp to 150,155,859 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000165; MAPK cascade
GO:0006024; glycosaminoglycan biosynthetic process
GO:0007165; signal transduction
GO:0007186; G-protein coupled receptor signaling pathway
GO:0007568; aging
GO:0008284; positive regulation of cell proliferation
GO:0008584; male gonad development
GO:0009636; response to toxic substance
GO:0010863; positive regulation of phospholipase C activity
GO:0014066; regulation of phosphatidylinositol 3-kinase signaling
GO:0014068; positive regulation of phosphatidylinositol 3-kinase signaling
And 54 more GO terms Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005886; plasma membrane
GO:0005925; focal adhesion
GO:0009986; cell surface
GO:0016020; membrane
GO:0016021; integral component of membrane
GO:0016324; apical plasma membrane
GO:0031226; intrinsic component of plasma membrane
GO:0031410; cytoplasmic vesicle
GO:0043202; lysosomal lumen
And 2 more GO terms
Show all GO termsFunction: GO:0004713; protein tyrosine kinase activity
GO:0004992; platelet activating factor receptor activity
GO:0005017; platelet-derived growth factor-activated receptor activity
GO:0005019; platelet-derived growth factor beta-receptor activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005102; receptor binding
GO:0005161; platelet-derived growth factor receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0019899; enzyme binding
GO:0019901; protein kinase binding
And 5 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- SHC1, PTPN11, STAT3, STAT5A, EGFR, PDGFB, PDGFRB, PTEN, HSP90AA1, GRB2, PIK3R1, PDGFRA
- STRING interaction network
