GenAge entry for PDGFB (Homo sapiens)

Gene name (HAGRID: 47)

HGNC symbol: PDGFB
Aliases: SSV; SIS
Common name: platelet-derived growth factor beta polypeptide

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: PDGFB is a mitogen and oncogene involved in cell survival, development, and healing [363]. Results from rats suggest it may be related to age-related changes in the heart [362], and PDGF's anti-apoptotic signalling involves several pathways and genes that in turn have been associated with ageing [333]. PDGFB's exact relevance to human ageing, however, is unknown.

Cytogenetic information

Cytogenetic band: 22q13.1
Location: 39,223,680 bp to 39,244,952 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000165; MAPK cascade
GO:0001892; embryonic placenta development
GO:0001938; positive regulation of endothelial cell proliferation
GO:0002548; monocyte chemotaxis
GO:0002576; platelet degranulation
GO:0003104; positive regulation of glomerular filtration
GO:0006468; protein phosphorylation
GO:0007179; transforming growth factor beta receptor signaling pathway
GO:0007507; heart development
GO:0008284; positive regulation of cell proliferation
GO:0009611; response to wounding

And 59 more GO terms

Cellular component:

GO:0000139; Golgi membrane
GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005737; cytoplasm
GO:0005788; endoplasmic reticulum lumen
GO:0009986; cell surface
GO:0016323; basolateral plasma membrane
GO:0031012; extracellular matrix
GO:0031093; platelet alpha granule lumen

Function:

GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005161; platelet-derived growth factor receptor binding
GO:0005515; protein binding
GO:0005518; collagen binding
GO:0008083; growth factor activity
GO:0016176; superoxide-generating NADPH oxidase activator activity
GO:0042056; chemoattractant activity
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982; protein heterodimerization activity

And 2 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: PDGFB, PDGFRB, PDGFRA
STRING interaction network

Retrieve sequences for PDGFB

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Mus musculus: Pdgfb
Rattus norvegicus: Pdgfb

In other databases

CellAge

This gene is present as PDGFB