GenAge entry for RET (Homo sapiens)

Gene name (HAGRID: 56)

HGNC symbol
RET 
Aliases
PTC; CDHF12; RET51; CDHR16; HSCR1; MEN2A; MTC1; MEN2B 
Common name
ret proto-oncogene 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

A receptor tyrosine kinase that is also considered an oncogene, RET promotes cellular growth. Its levels increase with age in the nervous system [215], and it has been related to cancer, but at present there is no evidence to suggest it plays a major role in human ageing.

Cytogenetic information

Cytogenetic band
10q11.2
Location
43,077,069 bp to 43,130,349 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000165; MAPK cascade
GO:0001657; ureteric bud development
GO:0001755; neural crest cell migration
GO:0001838; embryonic epithelial tube formation
GO:0006468; protein phosphorylation
GO:0007156; homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007158; neuron cell-cell adhesion
GO:0007165; signal transduction
GO:0007169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007497; posterior midgut development
GO:0010976; positive regulation of neuron projection development
GO:0014042; positive regulation of neuron maturation
GO:0018108; peptidyl-tyrosine phosphorylation
GO:0030155; regulation of cell adhesion
GO:0030335; positive regulation of cell migration
GO:0033619; membrane protein proteolysis
GO:0033630; positive regulation of cell adhesion mediated by integrin
GO:0035799; ureter maturation
GO:0042493; response to drug
GO:0042551; neuron maturation
GO:0043547; positive regulation of GTPase activity
GO:0045793; positive regulation of cell size
GO:0045893; positive regulation of transcription, DNA-templated
GO:0048265; response to pain
GO:0048484; enteric nervous system development
GO:0050770; regulation of axonogenesis
GO:0060041; retina development in camera-type eye
GO:0060384; innervation
GO:0061146; Peyer's patch morphogenesis
GO:0071300; cellular response to retinoic acid
GO:0072300; positive regulation of metanephric glomerulus development
GO:0097021; lymphocyte migration into lymphoid organs
GO:1903263; positive regulation of serine phosphorylation of STAT3 protein
GO:2001241; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular component: GO:0005737; cytoplasm
GO:0005769; early endosome
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0010008; endosome membrane
GO:0030424; axon
GO:0030425; dendrite
GO:0043025; neuronal cell body
GO:0043231; intracellular membrane-bounded organelle
GO:0043235; receptor complex
GO:0045121; membrane raft
Function: GO:0004713; protein tyrosine kinase activity
GO:0004714; transmembrane receptor protein tyrosine kinase activity
GO:0004872; receptor activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005509; calcium ion binding
GO:0005515; protein binding
GO:0005524; ATP binding
Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, STAT3, EGFR, RET, HSP90AA1, GRB2, PTK2, MAPK3
STRING interaction network
Protein-Protein network diagram for RET

Retrieve sequences for RET

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
ret
Drosophila melanogaster
Ret
Mus musculus
Ret
Rattus norvegicus
Ret

Selected references

External links

EPD
ORF Accession
NM_020975
CDS Accession
NP_066124
OMIM
164761
HPRD
01266
Ensembl
RET
UniProt/Swiss-Prot
RET_HUMAN
GeneCards
RET
Entrez Gene
5979
UniGene
350321
GenAtlas
RET
Internet
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