GenDR Dietary Restriction Gene Manipulation: Ire1
Gene Information (Entrez Gene ID: 42358)
- Symbol
- Ire1
- Aliases
- CG4583 dire-1 dIRE1 Dmel\CG4583 Ire ire-1 Ire-1 IRE-like ire1 IRE1
- Name
- Inositol-requiring enzyme-1
- Organism
- Drosophila melanogaster (AnAge)
- Entrez Gene ID
- 42358
Potential relevance to dietary restriction and ageing
- Observations
-
Whole body depletion of Ire1 using RNA interference reduced lifespan in flies and negated the lifespan extending effects of dietary restriction. This effect was found to be tissue specific, Ire1 expression in the midgut is required for starvation tolerance and lifespan extension.
- References
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In other databases
- GenAge model organism genes
- GenDR gene manipulations
Homologs
- Caenorhabditis elegans
- ire-1
- Danio rerio
- ern2
- Homo sapiens
- ERN2
- Mus musculus
- Ern2
- Rattus norvegicus
- Ern2
- Saccharomyces cerevisiae
- IRE1
- Schizosaccharomyces pombe
- ppk4
External links
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 42358
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar