LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Ashkenazi Jewish
- Study Design
- 205 centenarians (141 females, median age = 97 years and 64 males, median age = 97 years), their offspring (n = 145 total, 80 females, median age = 69 years and 65 males median age = 68 years), and 288 controls (167 females, median age = 74 years and 121 males, median age = 75 years) were examined for the association between genotype and longevity
- Conclusions
- A U-shape pattern of MTP CC genotype frequency with aging was observed. The CC was a buffered-deleterious genotype in the case group. In the control group without longevity genes, CC genotype included poorer survivorship.
Gene details
- HGNC symbol
- MTTP
- Aliases
- ABL; MTP
- Common name
- microsomal triglyceride transfer protein
- Description
- MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 20
- OMIM
- 157147
- Ensembl
- ENSG00000138823
- UniProt/Swiss-Prot
- B7Z7X3_HUMAN
- Entrez Gene
- 4547
- UniGene
- 195799
- HapMap
- View on HapMap