LongevityMap variant

Entry Details

Longevity Association
Non-significant
Population
English (Oxford)
Study Design
11 SNPs in the MTTP gene were genotyped in 1451 old people (mean age: 77.9 ± 0.2 years) and 777 controls (30- 50 years, mean age: 40.6 ± 0.2 years) to study association with longevity
Conclusions
MTTP gene variants were not significant association with longevity
Identifier
rs2866164
In Other Studies (IDs)
432 1945 2082 3461
Cytogenetic Location
4q23
UCSC Genome Browser
View 4q23 on the UCSC genome browser

Gene details

HGNC symbol
MTTP
Aliases
ABL; MTP 
Common name
microsomal triglyceride transfer protein 
Description
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
20
OMIM
157147
Ensembl
ENSG00000138823
UniProt/Swiss-Prot
B7Z7X3_HUMAN
Entrez Gene
4547
UniGene
195799
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
mtp
Drosophila melanogaster
Mtp
Mus musculus
Mttp
Rattus norvegicus
Mttp

References

Neville et al. (2007)

Other variants which are also part of this study