LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- rs1800591, rs2866164, and Q/H 95 SNPs were examined in 1,039 unrelated individuals between 95 and 109 years of age (mean age, 98.2 years); 373 (36%) of the long-lived participants were centenarians or supercentenarians (mean age, 101.4 years). The sex ratio in the entire sample was 74% females vs. 26% males. A total of 540 control individuals aged between 60 and 75 years (mean age, 67.2 years) were used.
- Conclusions
- No evidence for association was detected between any of the tested SNPs at the allele or at the genotype level
Gene details
- HGNC symbol
- MTTP
- Aliases
- ABL; MTP
- Common name
- microsomal triglyceride transfer protein
- Description
- MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 20
- OMIM
- 157147
- Ensembl
- ENSG00000138823
- UniProt/Swiss-Prot
- B7Z7X3_HUMAN
- Entrez Gene
- 4547
- UniGene
- 195799
- HapMap
- View on HapMap