LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Identifier
- rs12013673
- In Other Studies (IDs)
- 1628
- Cytogenetic Location
- Xq13.1
- UCSC Genome Browser
- View Xq13.1 on the UCSC genome browser
Gene details
- HGNC symbol
- FOXO4
- Aliases
- AFX; AFX1; MLLT7
- Common name
- forkhead box O4
- Description
- This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
- Other longevity studies of this gene
- 5
- OMIM
- 300033
- Ensembl
- ENSG00000184481
- UniProt/Swiss-Prot
- FOXO4_HUMAN
- Entrez Gene
- 4303
- UniGene
- 584654
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- LOC563719
- Drosophila melanogaster
- foxo
- Mus musculus
- Foxo4
- Rattus norvegicus
- Foxo4
- Saccharomyces cerevisiae
- FHL1
- Schizosaccharomyces pombe
- sep1