The AGO2 gene and its putative association with human ageing

Cell Senescence Entries for AGO2

Cell Types: Embryonic kidney
Cell Lines: HEK293
Cancer Cell?: No
Method: Overexpression
Type of senescence: Oncogene-induced
Senescence Effect: Inhibits
Primary Reference: Yang et al. (2014) Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence. Mol Cell 55(5)782-90 (PubMed)

AGO2 Gene Information

HGNC symbol: AGO2
Aliases: CASC7; EIF2C2; hAGO2; LINC00980; Q10
Common name: argonaute RISC catalytic component 2
Entrez Id: 27161
Description: This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

AGO2 Ontologies

Gene Ontology

Process:

GO:90502; RNA phosphodiester bond hydrolysis, endonucleolytic
GO:6412; translation
GO:6355; regulation of transcription, DNA-templated
GO:6417; regulation of translation
GO:90305; nucleic acid phosphodiester bond hydrolysis
GO:31047; gene silencing by RNA
GO:6413; translational initiation
GO:60213; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:1900153; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45766; positive regulation of angiogenesis

And 20 more GO terms

Cellular component:	GO:5737; cytoplasm GO:5634; nucleus GO:16020; membrane GO:5829; cytosol GO:1990904; ribonucleoprotein complex GO:36464; cytoplasmic ribonucleoprotein granule GO:932; P-body GO:16442; RISC complex GO:5654; nucleoplasm GO:5845; mRNA cap binding complex GO:70578; RISC-loading complex
	And 4 more GO terms

Function:	GO:35198; miRNA binding GO:5515; protein binding GO:3676; nucleic acid binding GO:3723; RNA binding GO:3743; translation initiation factor activity GO:46872; metal ion binding GO:16787; hydrolase activity GO:4518; nuclease activity GO:4519; endonuclease activity GO:340; RNA 7-methylguanosine cap binding GO:3727; single-stranded RNA binding
	And 12 more GO terms

Show all GO terms

Homologs of AGO2 in Model Organisms

Danio rerio: CU929240.1
Drosophila melanogaster: AGO1
Mus musculus: Eif2c2
Rattus norvegicus: Eif2c2
Schizosaccharomyces pombe: ago1

Cell Senescence Entries for AGO2

AGO2 Gene Information

AGO2 Ontologies

Homologs of AGO2 in Model Organisms

External links