Cell Senescence Entries for AKT1S1
- Cell Types
- Osteosarcoma
- Cell Lines
- U2OS
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Havel et al. (2015) Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway. Oncogene 34(12)1487-98 (PubMed)
AKT1S1 Gene Information
- HGNC symbol
- AKT1S1
- Aliases
- Lobe; MGC2865; PRAS40
- Common name
- AKT1 substrate 1
- Entrez Id
- 84335
- Description
- AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008].
AKT1S1 Ontologies
- Gene Ontology
-
Process: GO:32007; negative regulation of TOR signaling
GO:48011; neurotrophin TRK receptor signaling pathway
GO:42981; regulation of apoptotic process
GO:6469; negative regulation of protein kinase activity
GO:43523; regulation of neuron apoptotic process
GO:45792; negative regulation of cell size
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:5654; nucleoplasm
GO:31931; TORC1 complex
Show all GO termsFunction: GO:5515; protein binding
Homologs of AKT1S1 in Model Organisms
In other databases
- LongevityMap
- This gene is present as AKT1S1
External links
- OMIM
- 610221
- Ensembl
- ENSG00000204673
- Entrez Gene
- 84335
- UniGene
- 610819
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- AKT1S1
- GeneCards
- AKT1S1