Cell Senescence Entries for AR

Cell Types
Hair follicular keratinocyte
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Yang et al. (2014) Androgen receptor accelerates premature senescence of human dermal papilla cells in association with DNA damage. PLoS One 8(11)e79434 (PubMed)

AR Gene Information

HGNC symbol
AR 
Aliases
AIS; DHTR; HUMARA; NR3C4; SBMA; SMAX1 
Common name
androgen receptor 
Entrez Id
367
Description
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017].

AR Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:30521; androgen receptor signaling pathway
GO:8285; negative regulation of cell population proliferation
GO:10628; positive regulation of gene expression
GO:8284; positive regulation of cell population proliferation
GO:7165; signal transduction
GO:7267; cell-cell signaling
GO:51092; positive regulation of NF-kappaB transcription factor activity
And 46 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:5654; nucleoplasm
GO:785; chromatin
GO:32991; protein-containing complex
GO:16607; nuclear speck
GO:5886; plasma membrane
Function: GO:5515; protein binding
GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:4879; nuclear receptor activity
GO:8289; lipid binding
GO:5102; signaling receptor binding
GO:19899; enzyme binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
And 13 more GO terms
Show all GO terms

Homologs of AR in Model Organisms

Danio rerio
ar
Mus musculus
Ar
Rattus norvegicus
Ar

In other databases

GenAge human genes
  • This gene is present as AR

External links

OMIM
313700
Ensembl
ENSG00000169083
Entrez Gene
367
UniGene
76704
1000 Genomes
1000 Genomes
HPRD
GenAtlas
AR
GeneCards
AR