Cell Senescence Entries for ARID4B
- Cell Types
- Lung cancer
- Cell Lines
- H1299
- Cancer Cell?
- Yes
- Method
- Mutation, Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Binda et al. (2006) RBP1 family proteins exhibit SUMOylation-dependent transcriptional repression and induce cell growth inhibition reminiscent of senescence. Mol Cell Biol 26(5)1917-31 (PubMed)
ARID4B Gene Information
- HGNC symbol
- ARID4B
- Aliases
- BCAA; BRCAA1; RBP1L1; SAP180
- Common name
- AT-rich interaction domain 4B
- Entrez Id
- 51742
- Description
- This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008].
ARID4B Ontologies
- Gene Ontology
-
Process: GO:6355; regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:6357; regulation of transcription by RNA polymerase II
GO:8150; biological_process
GO:122; negative regulation of transcription by RNA polymerase II
GO:30336; negative regulation of cell migration
GO:1902459; positive regulation of stem cell population maintenance
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:1902455; negative regulation of stem cell population maintenance
GO:6349; regulation of gene expression by genetic imprinting
GO:7283; spermatogenesis
And 5 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5739; mitochondrion
GO:16580; Sin3 complex
Function: GO:3677; DNA binding
GO:5515; protein binding
GO:976; transcription cis-regulatory region binding
GO:3674; molecular_function
Homologs of ARID4B in Model Organisms
- Danio rerio
- ch1073-321c8.1
- Drosophila melanogaster
- CG34422
- Mus musculus
- Arid4b
- Rattus norvegicus
- Arid4b
External links
- OMIM
- 609696
- Ensembl
- ENSG00000054267
- Entrez Gene
- 51742
- UniGene
- 575782
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ARID4B
- GeneCards
- ARID4B