Cell Senescence Entries for ASAH1

Cell Types
Epithelial melanoma
Cell Lines
A375
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lai et al. (2019) Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells. Sci Rep 7(1)7411 (PubMed)

ASAH1 Gene Information

HGNC symbol
ASAH1 
Aliases
AC; ACDase; ASAH; FLJ21558; PHP32 
Common name
N-acylsphingosine amidohydrolase 1 
Entrez Id
427
Description
This gene encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. Processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid. This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene are associated with the lysosomal storage disorder, Farber lipogranulomatosis, and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy. [provided by RefSeq, Oct 2015].

ASAH1 Ontologies

Gene Ontology
Process: GO:6629; lipid metabolic process
GO:6665; sphingolipid metabolic process
GO:6631; fatty acid metabolic process
GO:71356; cellular response to tumor necrosis factor
GO:46512; sphingosine biosynthetic process
GO:46513; ceramide biosynthetic process
GO:30216; keratinocyte differentiation
GO:50810; regulation of steroid biosynthetic process
GO:46514; ceramide catabolic process
GO:62098; regulation of programmed necrotic cell death
GO:45892; negative regulation of transcription, DNA-templated
And 2 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5576; extracellular region
GO:5615; extracellular space
GO:5764; lysosome
GO:70062; extracellular exosome
GO:1904813; ficolin-1-rich granule lumen
GO:1904724; tertiary granule lumen
GO:43202; lysosomal lumen
GO:16020; membrane
GO:16021; integral component of membrane
And 1 more GO terms
Function: GO:16787; hydrolase activity
GO:17040; N-acylsphingosine amidohydrolase activity
GO:102121; ceramidase activity
GO:17064; fatty acid amide hydrolase activity
GO:16811; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:16810; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:3714; transcription corepressor activity
GO:16922; nuclear receptor binding
GO:5515; protein binding
Show all GO terms

Homologs of ASAH1 in Model Organisms

Caenorhabditis elegans
asah-1
Danio rerio
asah1a
Mus musculus
Asah1
Rattus norvegicus
Asah1

In other databases

CellAge gene expression
  • This gene is present as ASAH1

External links

OMIM
613468
Ensembl
ENSG00000104763
Entrez Gene
427
UniGene
633993
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ASAH1
GeneCards
ASAH1