Cell Senescence Entries for BNIP3L

Cell Types
Foreskin fibroblast, Melanocyte
Cell Lines
BJ, Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Wajapeyee et al. (2008) Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 132(3)363-74 (PubMed)

BNIP3L Gene Information

HGNC symbol
BNIP3L 
Aliases
BNIP3a; Nix 
Common name
BCL2 interacting protein 3 like 
Entrez Id
665
Description
This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015].

BNIP3L Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:6915; apoptotic process
GO:51607; defense response to virus
GO:43065; positive regulation of apoptotic process
GO:71456; cellular response to hypoxia
GO:16239; positive regulation of macroautophagy
GO:60548; negative regulation of cell death
GO:35694; mitochondrial protein catabolic process
GO:43067; regulation of programmed cell death
GO:97345; mitochondrial outer membrane permeabilization
GO:1903146; regulation of autophagy of mitochondrion
And 2 more GO terms
Cellular component: GO:5634; nucleus
GO:16607; nuclear speck
GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5739; mitochondrion
GO:5741; mitochondrial outer membrane
GO:5635; nuclear envelope
GO:31224; intrinsic component of membrane
GO:5740; mitochondrial envelope
Function: GO:42802; identical protein binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:5521; lamin binding
Show all GO terms

Homologs of BNIP3L in Model Organisms

Caenorhabditis elegans
dct-1
Danio rerio
bnip3la
Mus musculus
Bnip3l
Rattus norvegicus
Bnip3l

External links

OMIM
605368
Ensembl
ENSG00000104765
Entrez Gene
665
UniGene
131226
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BNIP3L
GeneCards
BNIP3L