Cell Senescence Entries for BTG2

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Wheaton et al. (2011) BTG2 antagonizes Pin1 in response to mitogens and telomere disruption during replicative senescence. Aging Cell 9(5)747-60 (PubMed)

BTG2 Gene Information

HGNC symbol
BTG2 
Aliases
APRO1; MGC126063; MGC126064; PC3; TIS21 
Common name
BTG anti-proliferation factor 2 
Entrez Id
7832
Description
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq, Jul 2008].

BTG2 Ontologies

Gene Ontology
Process: GO:17148; negative regulation of translation
GO:8285; negative regulation of cell population proliferation
GO:31175; neuron projection development
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:45930; negative regulation of mitotic cell cycle
GO:60213; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:122; negative regulation of transcription by RNA polymerase II
GO:6479; protein methylation
GO:8306; associative learning
GO:9612; response to mechanical stimulus
And 14 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:70062; extracellular exosome
Function: GO:5515; protein binding
GO:3714; transcription corepressor activity
Show all GO terms

Homologs of BTG2 in Model Organisms

Danio rerio
btg2
Mus musculus
Btg2
Rattus norvegicus
Btg2

In other databases

CellAge gene expression
  • This gene is present as BTG2

External links

OMIM
601597
Ensembl
ENSG00000159388
Entrez Gene
7832
UniGene
519162
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BTG2
GeneCards
BTG2