Cell Senescence Entries for CAVIN1

Cell Types
Cervical cancer, Lung fibroblast
Cell Lines
HeLa, IMR-90, WI-38
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Bai et al. (2011) Regulation of cellular senescence by the essential caveolar component PTRF/Cavin-1. Cell Res 21(7)1088-101 (PubMed)

CAVIN1 Gene Information

HGNC symbol
CAVIN1 
Aliases
cavin-1; CGL4; PTRF 
Common name
caveolae associated protein 1 
Entrez Id
284119
Description
This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009].

CAVIN1 Ontologies

Gene Ontology
Process: GO:6353; DNA-templated transcription, termination
GO:2000147; positive regulation of cell motility
GO:9303; rRNA transcription
GO:6363; termination of RNA polymerase I transcription
GO:6361; transcription initiation from RNA polymerase I promoter
GO:9306; protein secretion
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:43231; intracellular membrane-bounded organelle
GO:5783; endoplasmic reticulum
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:5901; caveola
GO:5829; cytosol
GO:45121; membrane raft
GO:5654; nucleoplasm
And 2 more GO terms
Function: GO:3723; RNA binding
GO:5515; protein binding
GO:19843; rRNA binding
GO:42802; identical protein binding
GO:42134; rRNA primary transcript binding
Show all GO terms

Homologs of CAVIN1 in Model Organisms

Danio rerio
ptrfb
Mus musculus
Ptrf
Rattus norvegicus
Ptrf

External links

OMIM
603198
Ensembl
ENSG00000177469
Entrez Gene
284119
UniGene
437191
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CAVIN1
GeneCards
CAVIN1