Cell Senescence Entries for CCNA2
- Cell Types
- Melanoma
- Cell Lines
- A375P
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)
CCNA2 Gene Information
- HGNC symbol
- CCNA2
- Aliases
- CCN1; CCNA
- Common name
- cyclin A2
- Entrez Id
- 890
- Description
- The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016].
CCNA2 Ontologies
- Gene Ontology
-
Process: GO:7049; cell cycle
GO:51301; cell division
GO:86; G2/M transition of mitotic cell cycle
GO:6275; regulation of DNA replication
GO:79; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:44772; mitotic cell cycle phase transition
GO:7265; Ras protein signal transduction
GO:16572; histone phosphorylation
GO:31100; animal organ regeneration
GO:32355; response to estradiol
GO:33762; response to glucagon
And 14 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:307; cyclin-dependent protein kinase holoenzyme complex
GO:97124; cyclin A2-CDK2 complex
GO:1939; female pronucleus
GO:1940; male pronucleus
Show all GO termsFunction: GO:5515; protein binding
GO:19901; protein kinase binding
GO:19904; protein domain specific binding
GO:16538; cyclin-dependent protein serine/threonine kinase regulator activity
Homologs of CCNA2 in Model Organisms
In other databases
External links
- OMIM
- 123835
- Ensembl
- ENSG00000145386
- Entrez Gene
- 890
- UniGene
- 58974
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- CCNA2
- GeneCards
- CCNA2