The CDK5 gene and its putative association with human ageing

Cell Senescence Entries for CDK5

Cell Types: Osteosarcoma
Cell Lines: Saos-2
Cancer Cell?: Yes
Method: Knockdown
Type of senescence: Unclear
Senescence Effect: Induces
Primary Reference: Alexander et al. (2004) Cellular senescence requires CDK5 repression of Rac1 activity. Mol Cell Biol 24(7)2808-19 (PubMed)

HGNC symbol: CDK5
Aliases: PSSALRE
Common name: cyclin dependent kinase 5
Entrez Id: 1020
Description: This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].

Gene Ontology

Process:	GO:6468; protein phosphorylation GO:7049; cell cycle GO:16310; phosphorylation GO:6915; apoptotic process GO:51301; cell division GO:7399; nervous system development GO:48511; rhythmic process GO:18105; peptidyl-serine phosphorylation GO:51726; regulation of cell cycle GO:1764; neuron migration GO:1934; positive regulation of protein phosphorylation
	And 84 more GO terms

Cellular component:	GO:5634; nucleus GO:5737; cytoplasm GO:16020; membrane GO:5654; nucleoplasm GO:5886; plasma membrane GO:30054; cell junction GO:42995; cell projection GO:30425; dendrite GO:45202; synapse GO:30424; axon GO:43204; perikaryon
	And 17 more GO terms

Function:	GO:166; nucleotide binding GO:4672; protein kinase activity GO:4674; protein serine/threonine kinase activity GO:4712; protein serine/threonine/tyrosine kinase activity GO:5524; ATP binding GO:16301; kinase activity GO:16740; transferase activity GO:106310; protein serine kinase activity GO:50321; tau-protein kinase activity GO:5515; protein binding GO:2039; p53 binding
	And 11 more GO terms

Show all GO terms

GenAge model organism genes