Cell Senescence Entries for CDK5R1

Cell Types
Osteosarcoma
Cell Lines
Saos-2, U2OS
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Mao et al. (2010) p35 is required for CDK5 activation in cellular senescence. J Biol Chem 285(19)14671-80 (PubMed)

CDK5R1 Gene Information

HGNC symbol
CDK5R1 
Aliases
Nck5a; p35; p35nck5a 
Common name
cyclin dependent kinase 5 regulatory subunit 1 
Entrez Id
8851
Description
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008].

CDK5R1 Ontologies

Gene Ontology
Process: GO:48511; rhythmic process
GO:18105; peptidyl-serine phosphorylation
GO:226; microtubule cytoskeleton organization
GO:7420; brain development
GO:7213; G protein-coupled acetylcholine receptor signaling pathway
GO:7411; axon guidance
GO:30182; neuron differentiation
GO:31175; neuron projection development
GO:18107; peptidyl-threonine phosphorylation
GO:16241; regulation of macroautophagy
GO:48013; ephrin receptor signaling pathway
And 27 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:42995; cell projection
GO:30425; dendrite
GO:43005; neuron projection
GO:48471; perinuclear region of cytoplasm
GO:30424; axon
And 12 more GO terms
Function: GO:16301; kinase activity
GO:5509; calcium ion binding
GO:5515; protein binding
GO:61575; cyclin-dependent protein serine/threonine kinase activator activity
GO:19901; protein kinase binding
GO:43539; protein serine/threonine kinase activator activity
GO:4672; protein kinase activity
GO:45296; cadherin binding
GO:48487; beta-tubulin binding
GO:30295; protein kinase activator activity
GO:43014; alpha-tubulin binding
And 6 more GO terms
Show all GO terms

Homologs of CDK5R1 in Model Organisms

Danio rerio
cdk5r1b
Drosophila melanogaster
Cdk5alpha
Mus musculus
Cdk5r1
Rattus norvegicus
Cdk5r1

External links

OMIM
603460
Ensembl
ENSG00000176749
Entrez Gene
8851
UniGene
500015
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CDK5R1
GeneCards
CDK5R1