Cell Senescence Entries for CDKN2B
- Cell Types
- Glioblastoma
- Cell Lines
- T98G, U-251MG, U-373MG
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Induces
- Primary Reference
- Fuxe et al. (2000) Adenovirus-mediated overexpression of p15INK4B inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16INK4A. Cell Growth Differ 11(7)373-84 (PubMed)
CDKN2B Gene Information
- HGNC symbol
- CDKN2B
- Aliases
- CDK4I; INK4B; MTS2; P15; p15INK4b; TP15
- Common name
- cyclin dependent kinase inhibitor 2B
- Entrez Id
- 1030
- Description
- This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].
CDKN2B Ontologies
- Gene Ontology
-
Process: GO:7049; cell cycle
GO:16310; phosphorylation
GO:45736; negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:1889; liver development
GO:7568; aging
GO:8285; negative regulation of cell population proliferation
GO:14070; response to organic cyclic compound
GO:30858; positive regulation of epithelial cell differentiation
GO:34097; response to cytokine
GO:48536; spleen development
GO:60253; negative regulation of glial cell proliferation
And 13 more GO terms Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:5829; cytosol
Show all GO termsFunction: GO:16301; kinase activity
GO:5515; protein binding
GO:19901; protein kinase binding
GO:4861; cyclin-dependent protein serine/threonine kinase inhibitor activity
Homologs of CDKN2B in Model Organisms
- Danio rerio
- LOC100329528
- Mus musculus
- Cdkn2b
- Rattus norvegicus
- Cdkn2b
In other databases
- GenAge human genes
- This gene is present as CDKN2B
- LongevityMap
- This gene is present as CDKN2B
- CellAge gene expression
- This gene is present as CDKN2B
External links
- OMIM
- 600431
- Ensembl
- ENSG00000147883
- Entrez Gene
- 1030
- UniGene
- 72901
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- CDKN2B
- GeneCards
- CDKN2B