Cell Senescence Entries for CKB

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

CKB Gene Information

HGNC symbol
CKB 
Aliases
CKBB 
Common name
creatine kinase B 
Entrez Id
1152
Description
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008].

CKB Ontologies

Gene Ontology
Process: GO:16310; phosphorylation
GO:19752; carboxylic acid metabolic process
GO:46314; phosphocreatine biosynthetic process
GO:21762; substantia nigra development
GO:7420; brain development
GO:21549; cerebellum development
GO:30644; cellular chloride ion homeostasis
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:5739; mitochondrion
GO:5615; extracellular space
GO:70062; extracellular exosome
GO:5634; nucleus
GO:30425; dendrite
GO:43025; neuronal cell body
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:3824; catalytic activity
GO:16772; transferase activity, transferring phosphorus-containing groups
GO:4111; creatine kinase activity
GO:5515; protein binding
GO:31625; ubiquitin protein ligase binding
Show all GO terms

Homologs of CKB in Model Organisms

Danio rerio
ckba
Mus musculus
Ckb
Rattus norvegicus
Ckb

In other databases

GenAge microarray genes
  • This gene is present as CKB

External links

OMIM
123280
Ensembl
ENSG00000166165
Entrez Gene
1152
UniGene
173724
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CKB
GeneCards
CKB