Cell Senescence Entries for CNOT6L

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Mittal et al. (2011) The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence. Mol Biol Cell 22(6)748-58 (PubMed)

CNOT6L Gene Information

HGNC symbol
CNOT6L 
Aliases
Ccr4b; DKFZp434K098 
Common name
CCR4-NOT transcription complex subunit 6 like 
Entrez Id
246175
Description

CNOT6L Ontologies

Gene Ontology
Process: GO:6397; mRNA processing
GO:6417; regulation of translation
GO:90305; nucleic acid phosphodiester bond hydrolysis
GO:31047; gene silencing by RNA
GO:90503; RNA phosphodiester bond hydrolysis, exonucleolytic
GO:8284; positive regulation of cell population proliferation
GO:10606; positive regulation of cytoplasmic mRNA processing body assembly
GO:289; nuclear-transcribed mRNA poly(A) tail shortening
GO:288; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:61157; mRNA destabilization
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:30014; CCR4-NOT complex
Function: GO:46872; metal ion binding
GO:16787; hydrolase activity
GO:3824; catalytic activity
GO:4518; nuclease activity
GO:5515; protein binding
GO:4527; exonuclease activity
GO:4535; poly(A)-specific ribonuclease activity
GO:175; 3'-5'-exoribonuclease activity
Show all GO terms

Homologs of CNOT6L in Model Organisms

Danio rerio
pde12
Mus musculus
Cnot6l
Rattus norvegicus
Pde12
Saccharomyces cerevisiae
CCR4

External links

OMIM
618069
Ensembl
ENSG00000138767
Entrez Gene
246175
UniGene
592519
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CNOT6L
GeneCards
CNOT6L