Cell Senescence Entries for COX5B
- Cell Types
- Breast cancer
- Cell Lines
- MCF-7, MDA-MB-231, MDA-MB-468
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Gao et al. (2016) Loss of COX5B inhibits proliferation and promotes senescence via mitochondrial dysfunction in breast cancer. Oncotarget 6(41)43363-74 (PubMed)
COX5B Gene Information
- HGNC symbol
- COX5B
- Aliases
- Common name
- cytochrome c oxidase subunit 5B
- Entrez Id
- 1329
- Description
- Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme. [provided by RefSeq, Jul 2008].
COX5B Ontologies
- Gene Ontology
-
Process: GO:1902600; proton transmembrane transport
GO:6119; oxidative phosphorylation
GO:6123; mitochondrial electron transport, cytochrome c to oxygen
GO:7585; respiratory gaseous exchange by respiratory system
GO:45333; cellular respiration
Cellular component: GO:16020; membrane
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:5751; mitochondrial respiratory chain complex IV
GO:5740; mitochondrial envelope
GO:31966; mitochondrial membrane
Show all GO termsFunction: GO:46872; metal ion binding
GO:5515; protein binding
GO:4129; cytochrome-c oxidase activity
Homologs of COX5B in Model Organisms
- Caenorhabditis elegans
- cco-1
- Danio rerio
- zgc:86599
- Drosophila melanogaster
- CoVb
- Mus musculus
- Cox5b
- Rattus norvegicus
- Cox5b
- Saccharomyces cerevisiae
- COX4
- Schizosaccharomyces pombe
- cox4
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as cco-1
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as CoVb
External links
- OMIM
- 123866
- Ensembl
- ENSG00000135940
- Entrez Gene
- 1329
- UniGene
- 1342
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- COX5B
- GeneCards
- COX5B