Cell Senescence Entries for CUL4B

Cell Types
Foreskin fibroblast, Osteosarcoma
Cell Lines
Primary cell, U2OS
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Wei et al. (2016) CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop. Free Radic Biol Med 79(2)1-13 (PubMed)

CUL4B Gene Information

HGNC symbol
CUL4B 
Aliases
 
Common name
cullin 4B 
Entrez Id
8450
Description
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

CUL4B Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:16567; protein ubiquitination
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:6511; ubiquitin-dependent protein catabolic process
GO:42254; ribosome biogenesis
GO:31146; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:82; G1/S transition of mitotic cell cycle
GO:10498; proteasomal protein catabolic process
GO:35518; histone H2A monoubiquitination
GO:70914; UV-damage excision repair
And 5 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:31461; cullin-RING ubiquitin ligase complex
GO:70062; extracellular exosome
GO:80008; Cul4-RING E3 ubiquitin ligase complex
GO:31465; Cul4B-RING E3 ubiquitin ligase complex
GO:31464; Cul4A-RING E3 ubiquitin ligase complex
Function: GO:5515; protein binding
GO:31625; ubiquitin protein ligase binding
GO:3684; damaged DNA binding
GO:30674; protein-macromolecule adaptor activity
Show all GO terms

Homologs of CUL4B in Model Organisms

Danio rerio
cul4b
Mus musculus
Cul4b
Rattus norvegicus
Cul4b

External links

OMIM
300304
Ensembl
ENSG00000158290
Entrez Gene
8450
UniGene
102914
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CUL4B
GeneCards
CUL4B