Cell Senescence Entries for DMTF1

Cell Types
Foreskin fibroblast, Melanocyte
Cell Lines
BJ, Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Wajapeyee et al. (2008) Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 132(3)363-74 (PubMed)

DMTF1 Gene Information

HGNC symbol
DMTF1 
Aliases
DMP1; DMTF; hDMP1; MRUL 
Common name
cyclin D binding myb like transcription factor 1 
Entrez Id
9988
Description
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].

DMTF1 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
Show all GO terms

Homologs of DMTF1 in Model Organisms

Danio rerio
dmtf1
Mus musculus
Dmtf1
Rattus norvegicus
Dmtf1

External links

OMIM
608491
Ensembl
ENSG00000135164
Entrez Gene
9988
UniGene
196129
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DMTF1
GeneCards
DMTF1