Cell Senescence Entries for DNMT1

Cell Types
HUCB-MSCs
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
So et al. (2011) DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs. PLoS One 6(5)e19503 (PubMed)

DNMT1 Gene Information

HGNC symbol
DNMT1 
Aliases
CXXC9; DNMT; MCMT 
Common name
DNA methyltransferase 1 
Entrez Id
1786
Description
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].

DNMT1 Ontologies

Gene Ontology
Process: GO:1904707; positive regulation of vascular associated smooth muscle cell proliferation
GO:32259; methylation
GO:6325; chromatin organization
GO:90116; C-5 methylation of cytosine
GO:7265; Ras protein signal transduction
GO:10628; positive regulation of gene expression
GO:10629; negative regulation of gene expression
GO:122; negative regulation of transcription by RNA polymerase II
GO:6306; DNA methylation
GO:1905460; negative regulation of vascular associated smooth muscle cell apoptotic process
GO:51571; positive regulation of histone H3-K4 methylation
And 13 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:792; heterochromatin
GO:5657; replication fork
GO:5721; pericentric heterochromatin
Function: GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:8168; methyltransferase activity
GO:3677; DNA binding
GO:5515; protein binding
GO:3682; chromatin binding
GO:3886; DNA (cytosine-5-)-methyltransferase activity
GO:1990841; promoter-specific chromatin binding
GO:3723; RNA binding
GO:8327; methyl-CpG binding
And 2 more GO terms
Show all GO terms

Homologs of DNMT1 in Model Organisms

Danio rerio
dnmt1
Mus musculus
Dnmt1
Rattus norvegicus
Dnmt1

In other databases

CellAge gene expression
  • This gene is present as DNMT1

External links

OMIM
126375
Ensembl
ENSG00000130816
Entrez Gene
1786
UniGene
202672
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DNMT1
GeneCards
DNMT1