The DNMT3A gene and its putative association with human ageing

Cell Senescence Entries for DNMT3A

Cell Types: Colon cancer
Cell Lines: HCT116
Cancer Cell?: Yes
Method: Knockdown, Overexpression
Type of senescence: Stress-induced
Senescence Effect: Inhibits
Primary Reference: Zhang et al. (2011) DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cells. Int J Cancer 128(3)551-61 (PubMed)

DNMT3A Gene Information

HGNC symbol: DNMT3A
Aliases
Common name: DNA methyltransferase 3 alpha
Entrez Id: 1788
Description: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016].

DNMT3A Ontologies

Gene Ontology

Process:

GO:32259; methylation
GO:6325; chromatin organization
GO:6349; regulation of gene expression by genetic imprinting
GO:45892; negative regulation of transcription, DNA-templated
GO:6306; DNA methylation
GO:32776; DNA methylation on cytosine
GO:6479; protein methylation
GO:10468; regulation of gene expression
GO:122; negative regulation of transcription by RNA polymerase II
GO:90116; C-5 methylation of cytosine
GO:278; mitotic cell cycle

And 22 more GO terms

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5694; chromosome
GO:16363; nuclear matrix
GO:1902494; catalytic complex
GO:791; euchromatin
GO:775; chromosome, centromeric region
GO:792; heterochromatin
GO:1741; XY body

Function:

GO:46872; metal ion binding
GO:16740; transferase activity
GO:8168; methyltransferase activity
GO:3677; DNA binding
GO:5515; protein binding
GO:42802; identical protein binding
GO:3886; DNA (cytosine-5-)-methyltransferase activity
GO:9008; DNA-methyltransferase activity
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:3714; transcription corepressor activity

And 3 more GO terms

Show all GO terms

Homologs of DNMT3A in Model Organisms

Danio rerio: dnmt3ab
Mus musculus: Dnmt3a
Rattus norvegicus: Dnmt3a

Cell Senescence Entries for DNMT3A

DNMT3A Gene Information

DNMT3A Ontologies

Homologs of DNMT3A in Model Organisms

External links