Cell Senescence Entries for DUSP21
- Cell Types
- Hepatocellular carcinoma
- Cell Lines
- HCC
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Deng et al. (2014) RNA interference against cancer/testis genes identifies dual specificity phosphatase 21 as a potential therapeutic target in human hepatocellular carcinoma. Hepatology 59(2)518-30 (PubMed)
DUSP21 Gene Information
- HGNC symbol
- DUSP21
- Aliases
- Common name
- dual specificity phosphatase 21
- Entrez Id
- 63904
- Description
- This gene encodes a member of the dual specificity phosphatase family, specifically the low molecular weight dual specificity phosphatase family. The encoded protein localizes to both the cytoplasm and the nucleus and functions to remove phosphate groups from phosphotyrosine and phosphothreonine residues.[provided by RefSeq, Mar 2009].
DUSP21 Ontologies
- Gene Ontology
-
Process: GO:6470; protein dephosphorylation
GO:16311; dephosphorylation
GO:35335; peptidyl-tyrosine dephosphorylation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:5759; mitochondrial matrix
GO:31314; extrinsic component of mitochondrial inner membrane
Show all GO termsFunction: GO:16787; hydrolase activity
GO:4722; protein serine/threonine phosphatase activity
GO:4721; phosphoprotein phosphatase activity
GO:106306; protein serine phosphatase activity
GO:106307; protein threonine phosphatase activity
GO:5515; protein binding
GO:4725; protein tyrosine phosphatase activity
GO:16791; phosphatase activity
GO:8138; protein tyrosine/serine/threonine phosphatase activity
GO:17017; MAP kinase tyrosine/serine/threonine phosphatase activity
Homologs of DUSP21 in Model Organisms
External links
- OMIM
- 300678
- Ensembl
- ENSG00000189037
- Entrez Gene
- 63904
- UniGene
- 534478
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- DUSP21
- GeneCards
- DUSP21