Cell Senescence Entries for EHF

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Fujikawa et al. (2007) ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence. Cancer Sci 98(9)1468-75 (PubMed)

EHF Gene Information

HGNC symbol
EHF 
Aliases
ESE3; ESEJ 
Common name
ETS homologous factor 
Entrez Id
26298
Description
This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011].

EHF Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:6366; transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:30855; epithelial cell differentiation
GO:30154; cell differentiation
GO:50673; epithelial cell proliferation
Cellular component: GO:5634; nucleus
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:785; chromatin
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
Show all GO terms

Homologs of EHF in Model Organisms

Danio rerio
ehf
Mus musculus
Ehf
Rattus norvegicus
Ehf

External links

OMIM
605439
Ensembl
ENSG00000135373
Entrez Gene
26298
UniGene
653859
1000 Genomes
1000 Genomes
HPRD
GenAtlas
EHF
GeneCards
EHF