Cell Senescence Entries for EIF4EBP1
- Cell Types
- Lung fibroblast
- Cell Lines
- MRC-5
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Petroulakis et al. (2009) p53-dependent translational control of senescence and transformation via 4E-BPs. Cancer Cell 16(5)439-46 (PubMed)
EIF4EBP1 Gene Information
- HGNC symbol
- EIF4EBP1
- Aliases
- 4E-BP1; PHAS-I
- Common name
- eukaryotic translation initiation factor 4E binding protein 1
- Entrez Id
- 1978
- Description
- This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008].
EIF4EBP1 Ontologies
- Gene Ontology
-
Process: GO:6417; regulation of translation
GO:17148; negative regulation of translation
GO:45947; negative regulation of translational initiation
GO:82; G1/S transition of mitotic cell cycle
GO:45931; positive regulation of mitotic cell cycle
GO:31929; TOR signaling
Cellular component: GO:5829; cytosol
GO:5737; cytoplasm
Show all GO termsFunction: GO:8190; eukaryotic initiation factor 4E binding
GO:5515; protein binding
GO:30371; translation repressor activity
Homologs of EIF4EBP1 in Model Organisms
In other databases
External links
- OMIM
- 602223
- Ensembl
- ENSG00000187840
- Entrez Gene
- 1978
- UniGene
- 411641
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- EIF4EBP1
- GeneCards
- EIF4EBP1