Cell Senescence Entries for ENDOG

Cell Types
Endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Diener et al. (2010) Role of endonuclease G in senescence-associated cell death of human endothelial cells. Exp Gerontol 45(7-8)638-44 (PubMed)

ENDOG Gene Information

HGNC symbol
ENDOG 
Aliases
 
Common name
endonuclease G 
Entrez Id
2021
Description
The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008].

ENDOG Ontologies

Gene Ontology
Process: GO:90502; RNA phosphodiester bond hydrolysis, endonucleolytic
GO:6310; DNA recombination
GO:10508; positive regulation of autophagy
GO:1701; in utero embryonic development
GO:6309; apoptotic DNA fragmentation
GO:7568; aging
GO:9612; response to mechanical stimulus
GO:32007; negative regulation of TOR signaling
GO:32355; response to estradiol
GO:34599; cellular response to oxidative stress
GO:34612; response to tumor necrosis factor
And 12 more GO terms
Cellular component: GO:5739; mitochondrion
GO:5634; nucleus
GO:5829; cytosol
GO:43204; perikaryon
GO:5743; mitochondrial inner membrane
Function: GO:3676; nucleic acid binding
GO:46872; metal ion binding
GO:16787; hydrolase activity
GO:42803; protein homodimerization activity
GO:4518; nuclease activity
GO:5515; protein binding
GO:4519; endonuclease activity
GO:287; magnesium ion binding
GO:4521; endoribonuclease activity
GO:4520; endodeoxyribonuclease activity
GO:4536; deoxyribonuclease activity
And 2 more GO terms
Show all GO terms

Homologs of ENDOG in Model Organisms

Caenorhabditis elegans
cps-6
Danio rerio
endog
Drosophila melanogaster
EndoG
Mus musculus
Endog
Rattus norvegicus
Endog
Saccharomyces cerevisiae
NUC1
Schizosaccharomyces pombe
pnu1

External links

OMIM
600440
Ensembl
ENSG00000167136
Entrez Gene
2021
UniGene
745161
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ENDOG
GeneCards
ENDOG