Cell Senescence Entries for ERVW-1

Cell Types
Lung fibroblast, Mammary epithelial
Cell Lines
IMR-90, MCF-10A
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Chuprin et al. (2013) Cell fusion induced by ERVWE1 or measles virus causes cellular senescence. Genes Dev 27(21)2356-66 (PubMed)

ERVW-1 Gene Information

HGNC symbol
ERVW-1 
Aliases
envW; ERVWE1; HERV-7q; HERV-W; HERV-W-ENV; HERVW 
Common name
endogenous retrovirus group W member 1, envelope 
Entrez Id
30816
Description
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010].

ERVW-1 Ontologies

Gene Ontology
Process: GO:6949; syncytium formation
GO:9653; anatomical structure morphogenesis
GO:7520; myoblast fusion
GO:768; syncytium formation by plasma membrane fusion
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
Function:
Show all GO terms

Homologs of ERVW-1 in Model Organisms

No homologs found

External links

OMIM
604659
Ensembl
ENSG00000242950
Entrez Gene
30816
UniGene
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ERVW-1
GeneCards
ERVW-1