Cell Senescence Entries for FASN

Cell Types

Foreskin fibroblast

Cell Lines

HFFF2

Cancer Cell?

No

Method

Knockdown

Type of senescence

Oncogene-induced

Senescence Effect

Induces

Primary Reference

Fafián-Labora et al. (2020) FASN activity is important for the initial stages of the induction of senescence. Cell Death Dis 10(4)318 (PubMed)

FASN Gene Information

HGNC symbol

FASN 

Aliases

FAS; SDR27X1 

Common name

fatty acid synthase 

Entrez Id

2194

Description

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008].

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FASN Ontologies

Gene Ontology

Process:	GO:6629; lipid metabolic process GO:6631; fatty acid metabolic process GO:9058; biosynthetic process GO:6633; fatty acid biosynthetic process GO:8152; metabolic process GO:1649; osteoblast differentiation GO:2068; glandular epithelial cell development GO:6954; inflammatory response GO:8611; ether lipid biosynthetic process GO:9888; tissue development GO:30223; neutrophil differentiation
	And 5 more GO terms

Cellular component:

GO:5737; cytoplasm GO:16020; membrane GO:5794; Golgi apparatus GO:5829; cytosol GO:5886; plasma membrane GO:42470; melanosome GO:70062; extracellular exosome GO:42587; glycogen granule

Function:	GO:3723; RNA binding GO:16740; transferase activity GO:16491; oxidoreductase activity GO:16787; hydrolase activity GO:16829; lyase activity GO:16746; acyltransferase activity GO:3824; catalytic activity GO:5515; protein binding GO:4312; fatty acid synthase activity GO:4313; [acyl-carrier-protein] S-acetyltransferase activity GO:4314; [acyl-carrier-protein] S-malonyltransferase activity
	And 17 more GO terms

Show all GO terms

Homologs of FASN in Model Organisms

Caenorhabditis elegans

fasn-1

Danio rerio

fasn

Drosophila melanogaster

v(2)k05816

Mus musculus

Fasn

Rattus norvegicus

Fasn

External links

OMIM

600212

Ensembl

ENSG00000169710

Entrez Gene

2194

UniGene

83190

1000 Genomes

1000 Genomes

HPRD

GenAtlas

FASN

GeneCards

FASN