Cell Senescence Entries for FERMT1

Cell Types
Keratinocyte
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Piccinni et al. (2013) Induction of senescence pathways in Kindler syndrome primary keratinocytes. Br J Dermatol 168(5)1019-26 (PubMed)

FERMT1 Gene Information

HGNC symbol
FERMT1 
Aliases
C20orf42; FLJ20116; KIND1; UNC112A; URP1 
Common name
FERM domain containing kindlin 1 
Entrez Id
55612
Description
This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome. [provided by RefSeq, Dec 2009].

FERMT1 Ontologies

Gene Ontology
Process: GO:7155; cell adhesion
GO:7229; integrin-mediated signaling pathway
GO:7160; cell-matrix adhesion
GO:43616; keratinocyte proliferation
GO:90162; establishment of epithelial cell polarity
GO:51546; keratinocyte migration
GO:33625; positive regulation of integrin activation
GO:1903691; positive regulation of wound healing, spreading of epidermal cells
GO:1954; positive regulation of cell-matrix adhesion
GO:10629; negative regulation of gene expression
GO:30511; positive regulation of transforming growth factor beta receptor signaling pathway
And 8 more GO terms
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5886; plasma membrane
GO:5856; cytoskeleton
GO:5925; focal adhesion
GO:5829; cytosol
GO:30054; cell junction
GO:42995; cell projection
GO:32587; ruffle membrane
GO:30055; cell-substrate junction
GO:71944; cell periphery
And 1 more GO terms
Function: GO:5178; integrin binding
GO:51015; actin filament binding
Show all GO terms

Homologs of FERMT1 in Model Organisms

Danio rerio
fermt1
Mus musculus
Fermt1
Rattus norvegicus
Fermt1

External links

OMIM
607900
Ensembl
ENSG00000101311
Entrez Gene
55612
UniGene
472054
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FERMT1
GeneCards
FERMT1