Cell Senescence Entries for FIS1
- Cell Types
- Cervical cancer, Hepatoma
- Cell Lines
- ATCC, CCL-13, HeLa
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Lee et al. (2007) Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence. J Biol Chem 282(31)22977-83 (PubMed)
FIS1 Gene Information
- HGNC symbol
- FIS1
- Aliases
- CGI-135; H_NH0132A01.6; TTC11
- Common name
- fission, mitochondrial 1
- Entrez Id
- 51024
- Description
- The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008].
FIS1 Ontologies
- Gene Ontology
-
Process: GO:6915; apoptotic process
GO:6626; protein targeting to mitochondrion
GO:8053; mitochondrial fusion
GO:266; mitochondrial fission
GO:90141; positive regulation of mitochondrial fission
GO:90314; positive regulation of protein targeting to membrane
GO:422; autophagy of mitochondrion
GO:1836; release of cytochrome c from mitochondria
GO:70584; mitochondrion morphogenesis
GO:10821; regulation of mitochondrion organization
GO:16559; peroxisome fission
And 10 more GO terms Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:32991; protein-containing complex
GO:5739; mitochondrion
GO:5741; mitochondrial outer membrane
GO:5777; peroxisome
GO:5783; endoplasmic reticulum
GO:5778; peroxisomal membrane
GO:31307; integral component of mitochondrial outer membrane
GO:5829; cytosol
GO:5779; integral component of peroxisomal membrane
And 1 more GO terms
Show all GO termsFunction: GO:42802; identical protein binding
GO:5515; protein binding
Homologs of FIS1 in Model Organisms
- Caenorhabditis elegans
- fis-2
- Danio rerio
- uncharacterized_E9QG
- Drosophila melanogaster
- Fis1
- Mus musculus
- Fis1
- Rattus norvegicus
- Fis1
- Saccharomyces cerevisiae
- FIS1
- Schizosaccharomyces pombe
- fis1
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as FIS1
External links
- OMIM
- 609003
- Ensembl
- ENSG00000214253
- Entrez Gene
- 51024
- UniGene
- 423968
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- FIS1
- GeneCards
- FIS1