Cell Senescence Entries for FLT1

Cell Types
Umbilical vein endothelial
Cell Lines
HUVEC
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Nishi et al. (2008) Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt. Circ Res 103(3)261-8 (PubMed)

FLT1 Gene Information

HGNC symbol
FLT1 
Aliases
FLT; VEGFR1 
Common name
fms related receptor tyrosine kinase 1 
Entrez Id
2321
Description
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009].

FLT1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:7169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:18108; peptidyl-tyrosine phosphorylation
GO:30154; cell differentiation
GO:6935; chemotaxis
GO:1525; angiogenesis
GO:8284; positive regulation of cell population proliferation
GO:46777; protein autophosphorylation
GO:42327; positive regulation of phosphorylation
GO:31401; positive regulation of protein modification process
And 20 more GO terms
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5768; endosome
GO:5887; integral component of plasma membrane
GO:5576; extracellular region
GO:5925; focal adhesion
GO:15629; actin cytoskeleton
GO:5615; extracellular space
GO:43235; receptor complex
And 1 more GO terms
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4713; protein tyrosine kinase activity
GO:4714; transmembrane receptor protein tyrosine kinase activity
GO:5515; protein binding
GO:19838; growth factor binding
GO:5021; vascular endothelial growth factor-activated receptor activity
And 2 more GO terms
Show all GO terms

Homologs of FLT1 in Model Organisms

Danio rerio
flt1
Drosophila melanogaster
Pvr
Mus musculus
Flt1
Rattus norvegicus
Flt1

In other databases

GenAge human genes
  • This gene is present as FLT1

External links

OMIM
165070
Ensembl
ENSG00000102755
Entrez Gene
2321
UniGene
594454
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FLT1
GeneCards
FLT1