Cell Senescence Entries for FNTB
- Cell Types
- Breast cancer
- Cell Lines
- MCF-7
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Efimova et al. (2019) HMG-CoA Reductase Inhibition Delays DNA Repair and Promotes Senescence After Tumor Irradiation. Mol Cancer Ther 17(2)407-418 (PubMed)
FNTB Gene Information
- HGNC symbol
- FNTB
- Aliases
- FPTB
- Common name
- CHURC1-FNTB readthrough
- Entrez Id
- 100529261
- Description
- This locus represents naturally occurring read-through transcription between the neighboring CHURC1 (churchill domain containing 1) and FNTB (farnesyltransferase, CAAX box, beta) on chromosome 14. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011].
FNTB Ontologies
- Gene Ontology
-
Process: GO:45893; positive regulation of transcription, DNA-templated
GO:18343; protein farnesylation
GO:7275; multicellular organism development
GO:6629; lipid metabolic process
GO:18342; protein prenylation
Cellular component: GO:5965; protein farnesyltransferase complex
GO:5829; cytosol
GO:5875; microtubule associated complex
Show all GO termsFunction: GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:3824; catalytic activity
GO:4659; prenyltransferase activity
GO:4660; protein farnesyltransferase activity
GO:8318; protein prenyltransferase activity
GO:5515; protein binding
Homologs of FNTB in Model Organisms
No homologs found
External links
- OMIM
- NA
- Ensembl
- ENSG00000257365
- Entrez Gene
- 100529261
- UniGene
- 325531
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- FNTB
- GeneCards
- FNTB