Cell Senescence Entries for FXN

Cell Types
Bone marrow neuroblastoma
Cell Lines
SH-SY5Y
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Bolinches-Amorós et al. (2014) Mitochondrial dysfunction induced by frataxin deficiency is associated with cellular senescence and abnormal calcium metabolism. Front Cell Neurosci 8(2)124 (PubMed)

FXN Gene Information

HGNC symbol
FXN 
Aliases
CyaY; FA; FARR; FRDA; X25 
Common name
frataxin 
Entrez Id
2395
Description
This nuclear gene encodes a mitochondrial protein which belongs to the FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA from 8-33 repeats to >90 repeats results in Friedreich ataxia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016].

FXN Ontologies

Gene Ontology
Process: GO:16226; iron-sulfur cluster assembly
GO:43066; negative regulation of apoptotic process
GO:6811; ion transport
GO:6879; cellular iron ion homeostasis
GO:6119; oxidative phosphorylation
GO:6783; heme biosynthetic process
GO:7005; mitochondrion organization
GO:7628; adult walking behavior
GO:9060; aerobic respiration
GO:9792; embryo development ending in birth or egg hatching
GO:19230; proprioception
And 16 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5739; mitochondrion
GO:5829; cytosol
GO:5759; mitochondrial matrix
GO:1990229; iron-sulfur cluster assembly complex
GO:1990221; L-cysteine desulfurase complex
Function: GO:8199; ferric iron binding
GO:5515; protein binding
GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:4322; ferroxidase activity
GO:8198; ferrous iron binding
GO:34986; iron chaperone activity
GO:51537; 2 iron, 2 sulfur cluster binding
Show all GO terms

Homologs of FXN in Model Organisms

Danio rerio
fxn
Drosophila melanogaster
fh
Mus musculus
Fxn
Rattus norvegicus
Fxn
Schizosaccharomyces pombe
SPCC1183.03c

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Fxn
  • A homolog of this gene for Drosophila melanogaster is present as fh

External links

OMIM
606829
Ensembl
ENSG00000165060
Entrez Gene
2395
UniGene
20685
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FXN
GeneCards
FXN